Developing a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis …
M Shankar-Hari, GS Phillips, ML Levy, CW Seymour… - Jama, 2016 - jamanetwork.com
Importance Septic shock currently refers to a state of acute circulatory failure associated with
infection. Emerging biological insights and reported variation in epidemiology challenge the …
infection. Emerging biological insights and reported variation in epidemiology challenge the …
Lactate metabolism: historical context, prior misinterpretations, and current understanding
BS Ferguson, MJ Rogatzki, ML Goodwin… - European journal of …, 2018 - Springer
Lactate (La−) has long been at the center of controversy in research, clinical, and athletic
settings. Since its discovery in 1780, La− has often been erroneously viewed as simply a …
settings. Since its discovery in 1780, La− has often been erroneously viewed as simply a …
Prognostic accuracy of the serum lactate level, the SOFA score and the qSOFA score for mortality among adults with Sepsis
Z Liu, Z Meng, Y Li, J Zhao, S Wu, S Gou… - Scandinavian journal of …, 2019 - Springer
Background Sepsis is a common critical condition caused by the body's overwhelming
response to certain infective agents. Many biomarkers, including the serum lactate level …
response to certain infective agents. Many biomarkers, including the serum lactate level …
The value of blood lactate kinetics in critically ill patients: a systematic review
JL Vincent, A Quintairos e Silva, L Couto, FS Taccone - Critical care, 2016 - Springer
Background The time course of blood lactate levels could be helpful to assess a patient's
response to therapy. Although the focus of published studies has been largely on septic …
response to therapy. Although the focus of published studies has been largely on septic …
Lactic acidosis
JA Kraut, NE Madias - New England Journal of Medicine, 2014 - Mass Medical Soc
Lactic Acidosis | NEJM Skip to main content NEJM Group Follow Us Facebook Twitter
Instagram YouTube LinkedIn Prepare to become a physician, build your knowledge, lead a …
Instagram YouTube LinkedIn Prepare to become a physician, build your knowledge, lead a …
Comprehensive review on lactate metabolism in human health
M Adeva-Andany, M López-Ojén, R Funcasta-Calderón… - Mitochondrion, 2014 - Elsevier
Metabolic pathways involved in lactate metabolism are important to understand the
physiological response to exercise and the pathogenesis of prevalent diseases such as …
physiological response to exercise and the pathogenesis of prevalent diseases such as …
Energetic dysfunction in sepsis: a narrative review
Background Growing evidence associates organ dysfunction (s) with impaired metabolism
in sepsis. Recent research has increased our understanding of the role of substrate …
in sepsis. Recent research has increased our understanding of the role of substrate …
Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?
L Van Wyngene, J Vandewalle… - EMBO molecular medicine, 2018 - embopress.org
Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex
interplay of several pathways, including inflammation, immune activation, hypoxia, and …
interplay of several pathways, including inflammation, immune activation, hypoxia, and …
Severe hyperlactatemia, lactate clearance and mortality in unselected critically ill patients
SA Haas, T Lange, B Saugel, M Petzoldt… - Intensive care …, 2016 - Springer
Purpose Hyperlactatemia may occur for a variety of reasons and is a predictor of poor
clinical outcome. However, only limited data are available on the underlying causes of …
clinical outcome. However, only limited data are available on the underlying causes of …