[HTML][HTML] Complement system part I–molecular mechanisms of activation and regulation
NS Merle, SE Church, V Fremeaux-Bacchi… - Frontiers in …, 2015 - frontiersin.org
Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …
against pathogens and in host homeostasis. The complement system is initiated by …
[HTML][HTML] Complement receptors and their role in leukocyte recruitment and phagocytosis
S Vandendriessche, S Cambier, P Proost… - Frontiers in Cell and …, 2021 - frontiersin.org
The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …
activation generates a multitude of molecules that converge simultaneously on the …
Assessing the performance of the MM/PBSA and MM/GBSA methods. 6. Capability to predict protein–protein binding free energies and re-rank binding poses …
Understanding protein–protein interactions (PPIs) is quite important to elucidate crucial
biological processes and even design compounds that interfere with PPIs with …
biological processes and even design compounds that interfere with PPIs with …
Follicular dendritic cells: dynamic antigen libraries
BA Heesters, RC Myers, MC Carroll - Nature Reviews Immunology, 2014 - nature.com
Follicular dendritic cells (FDCs) are essential for high-affinity antibody production and for the
development of B cell memory. Historically, FDCs have been characterized as' …
development of B cell memory. Historically, FDCs have been characterized as' …
IgE in allergy and asthma today
HJ Gould, BJ Sutton - Nature Reviews Immunology, 2008 - nature.com
The spreading epidemic of allergies and asthma has heightened interest in IgE, the central
player in the allergic response. The activity of IgE is associated with a network of proteins; …
player in the allergic response. The activity of IgE is associated with a network of proteins; …
[PDF][PDF] Regulation of humoral immunity by complement
MC Carroll, DE Isenman - Immunity, 2012 - cell.com
The complement system of innate immunity is important in regulating humoral immunity
largely through the complement receptor CR2, which forms a coreceptor on B cells during …
largely through the complement receptor CR2, which forms a coreceptor on B cells during …
The biology of IGE and the basis of allergic disease
HJ Gould, BJ Sutton, AJ Beavil… - Annual review of …, 2003 - annualreviews.org
Allergic individuals exposed to minute quantities of allergen experience an immediate
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast …
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast …
Cancer vaccines and carbohydrate epitopes
Tumor-associated carbohydrate antigens (TACA) result from the aberrant glycosylation that
is seen with transformation to a tumor cell. The carbohydrate antigens that have been found …
is seen with transformation to a tumor cell. The carbohydrate antigens that have been found …
Structural basis for engagement by complement factor H of C3b on a self surface
HP Morgan, CQ Schmidt, M Guariento… - Nature structural & …, 2011 - nature.com
Complement factor H (FH) attenuates C3b molecules tethered by their thioester domains to
self surfaces and thereby protects host tissues. Factor H is a cofactor for initial C3b …
self surfaces and thereby protects host tissues. Factor H is a cofactor for initial C3b …
Genetic CD21 deficiency is associated with hypogammaglobulinemia
J Thiel, L Kimmig, U Salzer, M Grudzien… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Complement receptor 2 (CR2/CD21) is part of the B-cell coreceptor and
expressed by mature B cells and follicular dendritic cells. CD21 is a receptor for C3d …
expressed by mature B cells and follicular dendritic cells. CD21 is a receptor for C3d …