Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …

Osmoregulation is the active control of the cellular water balance and encompasses
homeostatic mechanisms crucial for life. The osmoregulatory system in the yeast …

Synonymous mutations in protein-coding genes do not alter protein sequences and are thus
generally presumed to be neutral or nearly neutral,,,–. Here, to experimentally verify this …

Strikingly consistent correlations between rates of coding-sequence evolution and gene
expression levels are apparent across taxa, but the biological causes behind the selective …

The basis of science is the hypothetico-deductive method and the recording of experiments
in sufficient detail to enable reproducibility. We report the development of Robot Scientist …

There is concern that the rate of environmental change is now exceeding the capacity of
many populations to adapt. Mitigation of biodiversity loss requires science that integrates …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …

It is not known whether evolution will usually be rapid enough to allow a species to adapt
and persist in a deteriorating environment. We tracked the eco-evolutionary dynamics of …

Functional genomic studies in Saccharomyces cerevisiae have contributed enormously to
our understanding of cellular processes. Their full potential, however, has been hampered …

Global quantitative analysis of genetic interactions is a powerful approach for deciphering
the roles of genes and mapping functional relationships among pathways. Using colony size …