More than a decade of research has shown that Sertoli cell proliferation is regulated by
thyroid hormone. Neonatal hypothyroidism lengthens the period of Sertoli cell proliferation …

Oligodendrocyte precursor cells (OPC) are glial cells that metamorphose into myelinating
oligodendrocytes during embryogenesis and early stages of post-natal life. OPCs continue …

Neuronal activity influences myelination of the brain, but the molecular mechanisms
involved are largely unknown. Here, we report that oligodendrocyte progenitor cells (OPCs) …

Allan-Herndon-Dudley syndrome (AHDS), a severe form of psychomotor retardation with
abnormal thyroid hormone (TH) parameters, is linked to mutations in the TH-specific …

Although both extrinsic and intrinsic factors have been identified that orchestrate the
differentiation and maturation of oligodendrocytes, less is known about the intracellular …

A multitude of factors regulate oligodendrocyte differentiation and remyelination, and to
elucidate the mechanisms underlying this process, we analyzed the interactions of known …

Retinoic acid (RA), the biologically active derivative of vitamin A, induces a variety of
embryonal carcinoma and neuroblastoma cell lines to differentiate into neurons. The …

Oligodendrocytes myelinate axons in the vertebrate central nervous system (CNS). They
develop from precursor cells (OPCs), some of which persist in the adult CNS. Adult OPCs …

In demyelinating diseases, such as multiple sclerosis, primary loss of myelin and
subsequent neuronal degeneration throughout the CNS impair patient functionality. While …

Microarray analysis of oligodendrocyte lineage cells purified by fluorescence-activated cell
sorting (FACS) from 2′, 3′-cyclic nucleotide 3′-phosphodiesterase (CNP)–enhanced …