Articular cartilage covers the ends of bone and provides shock absorption and lubrication to
the diarthrodial joints. Cartilage has a limited capacity for repair when injured, and there is a …

The liver is affected by many types of diseases, including metabolic disorders and acute liver
failure. Orthotopic liver transplantation (OLT) is currently the only effective treatment for life …

Direct conversion of somatic cells into neural stem cells (NSCs) by defined factors holds
great promise for mechanistic studies, drug screening, and potential cell therapies for …

We explored the underlying mechanisms of differentiation, dedifferentiation, reprogramming
and transdifferentiation (cell type switchings) from landscape and flux perspectives. Lineage …

Over the past decades, tremendous efforts have been made to establish pancreatic islet
transplantation as a standard therapy for type 1 diabetes. Recent advances in islet …

Regenerative medicine aims to repair and regenerate injured tissues and restore their
impaired functions. Recent developments in stem cell biology have attracted significant …

The repair of articular cartilage needs a sufficient number of chondrocytes to replace the
defect tissue, and therefore, expansion of cells is generally required. Chondrocytes derived …

Billions of dollars are annually invested in pharmaceutical industry and cosmetic sector with
intent to develop new drugs and treatment strategies for alopecia. Because the hair looks an …

The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in
the regulation of the physiology of the cardiovascular system. Several specific miRNAs were …

It is now well-established that somatic cells can be reprogrammed to alternative cell fates by
ectopic coexpression of defined factors. Reprogramming technology has uncovered a huge …