Women and men are suggested to have differences in vulnerability to neuropsychiatric
disorders, including major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Epidemiological studies have shown a positive relationship between dietary fat intake and
obesity. Since rats and mice show a similar relationship, they are considered an appropriate …

Dieting is the most common approach to losing weight for the majority of obese and
overweight individuals. Restricting intake leads to weight loss in the short term, but, by itself …

Insulin activates insulin receptors (InsRs) in the hypothalamus to signal satiety after a meal.
However, the rising incidence of obesity, which results in chronically elevated insulin levels …

Weight regain after weight loss is a substantial challenge in obesity therapeutics. Dieting
leads to significant adaptations in the homeostatic system that controls body weight, which …

The neuronal circuits involved in the regulation of feeding behavior and energy expenditure
are soft-wired, reflecting the relative activity of the postsynaptic neuronal system, including …

The adipocyte-derived hormone leptin is a peripheral signal that informs the brain about the
metabolic status of an organism. Although traditionally viewed as an appetite-suppressing …

The endogenous lipid signaling agent oleoylethanolamide (OEA) has recently been
described as a peripherally acting agent that reduces food intake and body weight gain in …

Although many persons with obesity can lose weight by lifestyle (diet and physical activity)
therapy, successful long‐term weight loss is difficult to achieve, and most people who lose …

Recent progress in the field of energy homeostasis was triggered by the discovery of
adipocyte hormone leptin and revealed a complex regulatory neuroendocrine network. A …