Chronic or intermittent hyperglycemia is associated with the development of diabetic
complications. Several signaling pathways can be altered by having hyperglycemia in …

Vascular smooth muscle (VSM) plays an important role in the regulation of vascular function.
Identifying the mechanisms of VSM contraction has been a major research goal in order to …

Vascular smooth muscle (VSM) plays an important role in maintaining vascular tone. In
addition to Ca 2+-dependent myosin light chain (MLC) phosphorylation, protein kinase C …

Type two diabetes (T2D) is a challenging metabolic disorder for which a cure has not yet
been found. Its etiology is associated with several phenomena, including significant loss of …

Abstract Background The Ebola virus is highly pathogenic and destructive to humans and
other primates. The Ebola virus encodes viral protein 40 (VP40), which is highly expressed …

The vascular basement membrane (BM) contains extracellular matrix (ECM) proteins that
assemble in a highly organized manner to form a supportive substratum for cell attachment …

Abstract Ethnopharmacological relevance Fructus Arctii is the dried ripe fruit of Arctium
lappa L.(family Asteraceae). It is a well-known Chinese Materia Medica that was included in …

Background Diabetic retinopathy (DR), currently considered as a neurovascular disease,
has become the major cause of blindness. More and more scholars believe that DR is no …

Hyperglycemia is one of the main causes of proliferative diabetic retinopathy (PDR)
characterized by thickening of the vascular basement membrane. Laminin alpha 1 (LAMA1) …

Hypertension and diabetes are multifactorial diseases that frequently coexist and
exacerbate each another. During the development of diabetes, the impairment of …