Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Glia are as numerous in the brain as neurons and widely known to serve supportive roles
such as structural scaffolding, extracellular ionic and neurotransmitter homeostasis, and …

Background Activation of microglia and astrocytes, a prominent hallmark of both aging and
Alzheimer's disease (AD), has been suggested to contribute to aging and AD progression …

Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to
active signaling and information processing in the brain. Contrary to this classical view, it is …

Astrocytes comprise a large population of cells in the brain and are important partners to
neighboring neurons, vascular cells, and other glial cells. Astrocytes not only form a scaffold …

We provide an overview of recent progress on the study of astrocyte intracellular Ca2+
signaling. We consider the methods that have been used to monitor astrocyte Ca2+ signals …

The spatiotemporal activities of astrocyte Ca 2+ signaling in mature neuronal circuits remain
unclear. We used genetically encoded Ca 2+ and glutamate indicators as well as …

Astrocytes have emerged as important partners of neurons in information processing.
Important progress has been made in the past two decades in understanding the role of …

Research on glutamatergic neurotransmission has focused mainly on the function of
presynaptic and postsynaptic neurons, leaving astrocytes with a secondary role only to …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …