Towards targeting of shared mechanisms of cancer metastasis and therapy resistance
F Weiss, D Lauffenburger, P Friedl - Nature Reviews Cancer, 2022 - nature.com
Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
A Dongre, RA Weinberg - Nature reviews Molecular cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …
Controversies around epithelial–mesenchymal plasticity in cancer metastasis
ED Williams, D Gao, A Redfern… - Nature Reviews Cancer, 2019 - nature.com
Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
T Shibue, RA Weinberg - Nature reviews Clinical oncology, 2017 - nature.com
The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …
[HTML][HTML] N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer
In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …
Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
Brief overview of prostate cancer statistics, grading, diagnosis and treatment strategies
H Schatten - Cell & molecular biology of prostate cancer: updates …, 2018 - Springer
This chapter provides a brief overview of prostate cancer statistics, grading, diagnosis and
treatment strategies that are discussed in more detail in the subsequent chapters of this …
treatment strategies that are discussed in more detail in the subsequent chapters of this …
[HTML][HTML] The role of TGF-β/SMAD4 signaling in cancer
Transforming growth factor β (TGF-β) signaling pathway plays important roles in many
biological processes, including cell growth, differentiation, apoptosis, migration, as well as …
biological processes, including cell growth, differentiation, apoptosis, migration, as well as …
[HTML][HTML] A systematic review of miR-29 in cancer
MicroRNAs (miRNA) are small non-coding RNAs (∼ 22 nt in length) that are known as
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …
A central role for cadherin signaling in cancer
A Kourtidis, R Lu, LJ Pence, PZ Anastasiadis - Experimental cell research, 2017 - Elsevier
Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …