Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …

Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

The success of anticancer therapy is usually limited by the development of drug resistance.
Such acquired resistance is driven, in part, by intratumoural heterogeneity—that is, the …

In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-
cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

This chapter provides a brief overview of prostate cancer statistics, grading, diagnosis and
treatment strategies that are discussed in more detail in the subsequent chapters of this …

Transforming growth factor β (TGF-β) signaling pathway plays important roles in many
biological processes, including cell growth, differentiation, apoptosis, migration, as well as …

MicroRNAs (miRNA) are small non-coding RNAs (∼ 22 nt in length) that are known as
potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a …

Cadherins are homophilic adhesion molecules with important functions in cell-cell adhesion,
tissue morphogenesis, and cancer. In epithelial cells, E-cadherin accumulates at areas of …