As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Despite the multiple ongoing and novel initiatives for developing brain-targeted drug
delivery systems, insurmountable obstacles remain. A perfect drug delivery device that can …

Short-term symptomatic treatment and dose-dependent side effects of pharmacological
treatment for neurodegenerative diseases have forced the medical community to seek an …

Neuroinflammation leads to neuronal stress responses that contribute to neuronal
dysfunction and loss. However, treatments that stabilize neurons and prevent their …

Neuronal loss is one of the striking causes of various central nervous system (CNS)
disorders, including major neurodegenerative diseases, such as Alzheimer's disease (AD) …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease commonly
diagnosed among the elderly population. AD is characterized by the loss of synaptic …

Background: Neuronal death is a major hallmark of Alzheimer's disease (AD). Necroptosis,
as a programmed necrotic process, is activated in AD. However, what signals and factors …

Background Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in the entire
physiopathological process and is critical to human health. Long-term imbalance in NAD+ …

Prolonging the healthy life span and limiting neurological illness are imperative goals in
gerontology. Age-related neurodegeneration is progressive and leads to severe diseases …

Neurodegenerative disorders are one of the most common causes of disability and
represent 6.3% of the global burden of disease. Among them, Alzheimer's, Parkinson's, and …