Terminal Cyclopropylsilyl Alcohols as Useful Key Units to Access 2, 3, 4, 6-Tetrasubstituted Tetrahydropyran Scaffolds by Stereocontrolled Prins Cyclization

LF Peña, A Barbero - Organic Letters, 2024 - ACS Publications
In this study, the use of terminal cyclopropylsilyl alcohols in Prins cyclization is reported as a
very efficient methodology for the preparation of polysubstituted tetrahydropyrans, in which …

Towards an efficient methodology for the synthesis of functionalized dihydropyrans by silyl-Prins cyclization: access to truncated natural products

LF Peña, P González-Andrés, A Barbero - RSC advances, 2024 - pubs.rsc.org
We herein present a selective methodology for the synthesis of disubstituted dihydropyrans
by silyl-Prins cyclization of Z-vinylsilyl alcohols mediated by trimethylsilyl …

Stereoselective Synthesis of Polysubstituted Tetrahydropyrans by Br ø nsted Acid‐Mediated Hydroxyalkoxylation of Silylated Alkenols

C Díez‐Poza, P Val, E López… - Asian Journal of Organic …, 2024 - Wiley Online Library
A convenient route for the preparation of tetrahydropyran (THP) derivatives with a
quaternary and tertiary vicinal stereocenters is reported. The atom economy acid‐catalyzed …

Metal‐free stereoselective synthesis of tetrahydropyrans bearing adjacent quaternary and tertiary stereocenters by acid mediated cyclization

C Díez-Poza, P Val, E López, A Barbero - Asian Journal of Organic … - Wiley Online Library
A convenient route for the preparation of tetrahydropyran (THP) derivatives with a
quaternary and tertiary vicinal stereocenters is reported. The atom economy acid‐catalyzed …