Alzheimer's disease: an updated overview of its genetics
J Andrade-Guerrero, A Santiago-Balmaseda… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …
classified as familial and sporadic. The dominant familial or autosomal presentation …
[HTML][HTML] Genetic architecture of Alzheimer's disease
Advances in genetic and genomic technologies over the last thirty years have greatly
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …
enhanced our knowledge concerning the genetic architecture of Alzheimer's disease (AD) …
Genome-wide analysis of genetic loci associated with Alzheimer disease
Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes
Objectives: To determine whether genotypes at CLU, PICALM, and CR1 confer risk for
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced …
Alzheimer disease (AD) and whether risk for AD associated with these genes is influenced …
Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?
K Mullane, M Williams - Biochemical pharmacology, 2013 - Elsevier
The worldwide incidence of Alzheimer's disease (AD) is increasing with estimates that 115
million individuals will have AD by 2050, creating an unsustainable healthcare challenge …
million individuals will have AD by 2050, creating an unsustainable healthcare challenge …
[HTML][HTML] The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE
RJ Guerreiro, DR Gustafson, J Hardy - Neurobiology of aging, 2012 - Elsevier
Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three
genes have been identified as the cause of early onset familial AD (EOAD). The most …
genes have been identified as the cause of early onset familial AD (EOAD). The most …
Research progress in the pathogenesis of Alzheimer's disease
YG Chen - Chinese medical journal, 2018 - mednexus.org
Objective: Alzheimer's disease (AD) is a kind of chronic degenerative disease of the central
nervous system, characteristics of cognitive dysfunction, and behavioral disability. The …
nervous system, characteristics of cognitive dysfunction, and behavioral disability. The …
A decade in psychiatric GWAS research
After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …
have led to many findings, most of which have been deposited into the GWAS Catalog …
Genetics of Alzheimer's disease
MEA Vilatela, M López-López… - Archives of medical …, 2012 - Elsevier
Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly and
represents an important and increasing clinical challenge in terms of diagnosis and …
represents an important and increasing clinical challenge in terms of diagnosis and …
Meta-analysis of the association between variants in SORL1 and Alzheimer disease
Objective To reexamine the association between the neuronal sortilin-related receptor gene
(SORL1) and Alzheimer disease (AD). Design Comprehensive and unbiased meta-analysis …
(SORL1) and Alzheimer disease (AD). Design Comprehensive and unbiased meta-analysis …