Energy demand of neurons in brain that is covered by glucose supply from the blood is
ensured by glucose transporters in capillaries and brain cells. In brain, the facilitative …

The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and
pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes …

The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

Under physiological conditions, the brain consumes over 20% of the whole body energy
supply. The blood-brain barrier (BBB) allows dynamic interactions between blood capillaries …

The neuroendocrine system governs essential survival and homeostatic functions. For
example, growth is needed for development, thermoregulation maintains optimal core …

The metabolic and energy state of the organism depends largely on the availability of
substrates, such as glucose for ATP production, necessary for maintaining physiological …

Glial cells perform critical functions that alter the metabolism and activity of neurons, and
there is increasing interest in their role in appetite and energy balance. Leptin, a key …

OBJECTIVE In healthy rodents, intestinal sugar absorption in response to sugar-rich meals
and insulin is regulated by GLUT2 in enterocyte plasma membranes. Loss of insulin action …

DNA methylation, one of the most well-studied epigenetic modifications, is involved in a
wide spectrum of biological processes. Epigenetic mechanisms control cellular morphology …

Neurons whose activity is regulated by glucose are found in a number of brain regions.
Glucose-excited (GE) neurons increase while glucose-inhibited (GI) neurons decrease their …