Morpholine as a privileged structure: A review on the medicinal chemistry and pharmacological activity of morpholine containing bioactive molecules
AP Kourounakis, D Xanthopoulos… - Medicinal Research …, 2020 - Wiley Online Library
Morpholine is a heterocycle featured in numerous approved and experimental drugs as well
as bioactive molecules. It is often employed in the field of medicinal chemistry for its …
as bioactive molecules. It is often employed in the field of medicinal chemistry for its …
Molecular mechanisms of amphetamines
MEA Reith, ME Gnegy - Substance use disorders: From etiology to …, 2020 - Springer
There is a plethora of amphetamine derivatives exerting stimulant, euphoric, anti-fatigue,
and hallucinogenic effects; all structural properties allowing these effects are contained …
and hallucinogenic effects; all structural properties allowing these effects are contained …
[HTML][HTML] Fluorinated phenmetrazine “legal highs” act as substrates for high-affinity monoamine transporters of the SLC6 family
FP Mayer, NV Burchardt, AM Decker, JS Partilla, Y Li… - …, 2018 - Elsevier
A variety of new psychoactive substances (NPS) are appearing in recreational drug markets
worldwide. NPS are compounds that target various receptors and transporters in the central …
worldwide. NPS are compounds that target various receptors and transporters in the central …
Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis
M Ashraf-Uz-Zaman, G Ji, D Tidwell, L Yin… - ACS chemical …, 2022 - ACS Publications
The dopaminergic system is involved in the regulation of immune responses in various
homeostatic and disease conditions. For conditions such as Parkinson's disease and …
homeostatic and disease conditions. For conditions such as Parkinson's disease and …
Exploring the Antiproliferative Potential of Morpholine‐Functionalized Aurones: Design, Synthesis, SAR, DFT, Hirshfeld Surface, 3D Energy Frameworks and …
In quest of generating a diverse array of potential cytotoxic candidates through molecular
hybridization approach, herein we have designed a library of forty‐one morpholine …
hybridization approach, herein we have designed a library of forty‐one morpholine …
[HTML][HTML] Unlocking the Potential of High-Quality Dopamine Transporter Pharmacological Data: Advancing Robust Machine Learning-Based QSAR Modeling
The dopamine transporter (DAT) plays a critical role in the central nervous system and has
been implicated in numerous psychiatric disorders. The ligand-based approaches are …
been implicated in numerous psychiatric disorders. The ligand-based approaches are …
[HTML][HTML] Rhizoctonia bataticola: From plant pathogen to a potential source of pharmaceutically relevant metabolites
Rhizoctonia bataticola is an anamorphic phytopathogenic fungus which acts as facultative
plant pathogens causing diseases to commercially important crops. The fungal metabolite …
plant pathogens causing diseases to commercially important crops. The fungal metabolite …
Structural and functional perspectives on interactions between synthetic cathinones and monoamine transporters.
VT Nguyen, AC Harris Jr, JM Eltit - Advances in Pharmacology (San …, 2023 - europepmc.org
Synthetic cathinone derivatives comprise a family of psychoactive compounds structurally
related to amphetamine. Over the last decade, clandestine chemists have synthesized a …
related to amphetamine. Over the last decade, clandestine chemists have synthesized a …
Evaluation of the reinforcing strength of phendimetrazine using a progressive-ratio schedule of reinforcement in rhesus monkeys
M Minkiewicz, PW Czoty, BE Blough… - Journal of Pharmacology …, 2020 - ASPET
Stimulant abuse is a persistent public health problem with no Food and Drug Administration–
approved pharmacotherapy. Although monoamine-releasing drugs such as d-amphetamine …
approved pharmacotherapy. Although monoamine-releasing drugs such as d-amphetamine …
Phentermine 및Phendimetrazine 으로유발된정신병적장애및양극성장애증례군연구.
김수영, 김태석, 김대진, 채정호… - Korean Journal of …, 2022 - search.ebscohost.com
Objectives Recently, weight loss has emerged as a national concern in South Korea, and
this has resulted in an increase in the frequency of use of central nervous system (CNS) …
this has resulted in an increase in the frequency of use of central nervous system (CNS) …