Ruthenium complexes as anticancer agents: A brief history and perspectives
SY Lee, CY Kim, TG Nam - Drug design, development and therapy, 2020 - Taylor & Francis
Platinum (Pt)-based anticancer drugs such as cisplatin have been used to treat various
cancers. However, they have some limitations including poor selectivity and toxicity towards …
cancers. However, they have some limitations including poor selectivity and toxicity towards …
Metal complexes in cancer therapy–an update from drug design perspective
U Ndagi, N Mhlongo, ME Soliman - Drug design, development and …, 2017 - Taylor & Francis
In the past, metal-based compounds were widely used in the treatment of disease
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …
conditions, but the lack of clear distinction between the therapeutic and toxic doses was a …
Ru(II)-p-Cymene Complexes of Furoylthiourea Ligands for Anticancer Applications against Breast Cancer Cells
DP Dorairaj, J Haribabu, M Dharmasivam… - Inorganic …, 2023 - ACS Publications
Half-sandwich Ru (II) complexes containing nitro-substituted furoylthiourea ligands, bearing
the general formula [(η 6-p-cymene) RuCl2 (L)](1–6) and [(η 6-p-cymene) RuCl …
the general formula [(η 6-p-cymene) RuCl2 (L)](1–6) and [(η 6-p-cymene) RuCl …
Investigation into antiproliferative activity and apoptosis mechanism of new arene Ru (ii) carbazole-based hydrazone complexes
Ruthenium complexes with bioactive ligands are becoming promising substitutes for
platinum complexes due to their precise action against various cancers. In the present study …
platinum complexes due to their precise action against various cancers. In the present study …
Liposome-based drug co-delivery systems in cancer cells
Combination therapy and nanotechnology offer a promising therapeutic method in cancer
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …
treatment. By improving drug's pharmacokinetics, nanoparticulate systems increase the …
Organometallic anticancer compounds
The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …
Piano stool Ru (II)-arene complexes having three monodentate legs: A comprehensive review on their development as anticancer therapeutics over the past decade
The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …
Metal complexes as DNA intercalators
HK Liu, PJ Sadler - Accounts of Chemical Research, 2011 - ACS Publications
DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its
derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this …
derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this …
Synthesis and Structure of Arene Ru(II) N∧O-Chelating Complexes: In Vitro Cytotoxicity and Cancer Cell Death Mechanism
A panel of six new structurally related organometallic arene Ru (II) complexes of general
composition [(η6-benzene) Ru (L) Cl](1–3) and [(η6-p-cymene) Ru (L) Cl](4–6)(L …
composition [(η6-benzene) Ru (L) Cl](1–3) and [(η6-p-cymene) Ru (L) Cl](4–6)(L …
Intracellular catalysis with selected metal complexes and metallic nanoparticles: advances toward the development of catalytic metallodrugs
JJ Soldevila-Barreda, N Metzler-Nolte - Chemical reviews, 2019 - ACS Publications
Platinum-containing drugs (eg, cisplatin) are among the most frequently used
chemotherapeutic agents. Their tremendous success has spurred research and …
chemotherapeutic agents. Their tremendous success has spurred research and …