Introduction: Compounds incorporating guanidine moiety have found many practical
applications in diverse areas of chemistry, such as nucleophilic organocatalysis, anion …

The evolution of the melanocortin receptors (MCRs) is linked to the evolution of
adrenocorticotrophic hormone (ACTH), the melanocyte-stimulating hormones (MSHs), and …

Pyroglutamylated RF-amide peptide (QRFP) is a peptide hormone with a C-terminal RF-
amide motif. QRFP selectively activates a class A G-protein-coupled receptor (GPCR) …

RF-amide neuropeptides, with their typical Arg-Phe-NH 2 signature at their carboxyl C-
termini, belong to a lineage of peptides that spans almost the entire life tree. Throughout …

We have recently characterized bicarinalin as the most abundant peptide from the venom of
the ant Tetramorium bicarinatum. This antimicrobial peptide is active against …

The RFamide neuropeptide 26RFa was first isolated from the brain of the European green
frog on the basis of cross‐reactivity with antibodies raised against bovine neuropeptide FF …

A series of four fluorinated dipeptide analogues each containing a fluoro‐olefin moiety as
peptide bond surrogate has been designed and synthesized. These motifs have been …

Introduction: Peptides have gained renewed interest as candidate therapeutics. However, to
bring them to a broader clinical use, challenges such as the rational optimization of their …

The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the
pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The …

Staphylococcus aureus produces peptide toxins that it uses to respond to environmental
cues. We previously characterized PepA1, a peptide toxin from S. aureus, that induces lytic …