Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Immunomodulation of tumor‐associated macrophages (TAMs) into tumor‐inhibiting M1‐like
phenotype is a promising but challenging strategy. Cleverly, tumor cells overexpress CD47 …

Cancer vaccines have emerged as a powerful new tool for cancer immunotherapy.
Adjuvants are vaccine ingredients that enhance the strength, velocity, and duration of the …

Many therapeutically active molecules are non-soluble in aqueous systems, chemically and
biologically fragile or present severe side effects. Lipid-based nanoparticle (LBNP) systems …

Gene therapy by expression constructs or down-regulation of certain genes has shown great
potential for the treatment of various diseases. The wide clinical application of nucleic acid …

The development of targeted nanomedicines for cancer therapy has been an utmost focus of
research across different fields including materials science, nanotechnology, biotechnology …

Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

The delivery of nucleic acids with transient activity for genetic engineering is a promising
methodology with potential applications in the treatment of diseases ranging from cancer …

Although mRNA and siRNA have significant therapeutic potential, their simultaneous
delivery has not been previously explored. To facilitate the treatment of diseases associated …