The etiology of cholelithiasis in children and adolescents—a literature review

K Zdanowicz, J Daniluk, DM Lebensztejn… - International journal of …, 2022 - mdpi.com
The incidence of gallstone disease has increased in recent years. The pathogenesis of
cholelithiasis is not fully understood. The occurrence of the disease is influenced by both …

Update of variants identified in the pancreatic β‐cell KATP channel genes KCNJ11 and ABCC8 in individuals with congenital hyperinsulinism and diabetes

E De Franco, C Saint‐Martin, K Brusgaard… - Human …, 2020 - Wiley Online Library
The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic
variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP …

[PDF][PDF] Congenital hyperinsulinism: diagnosis and treatment update

H Demirbilek, K Hussain - Journal of clinical research in …, 2017 - jag.journalagent.com
Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Standardised practices in the networked management of congenital hyperinsulinism: a UK national collaborative consensus

MG Shaikh, AK Lucas-Herald, A Dastamani… - Frontiers in …, 2023 - frontiersin.org
Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent
hypoglycaemia in infants and young children caused by inappropriate insulin over …

Hyperinsulinemic hypoglycemia in children and adolescents: recent advances in understanding of pathophysiology and management

M Gϋemes, SA Rahman, RR Kapoor… - Reviews in Endocrine …, 2020 - Springer
Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

[HTML][HTML] International guidelines for the diagnosis and management of hyperinsulinism

DD De Leon, JB Arnoux, I Banerjee, I Bergada… - Hormone Research in …, 2024 - karger.com
Background: Hyperinsulinism (HI) due to dysregulation of pancreatic beta-cell insulin
secretion is the most common and most severe cause of persistent hypoglycemia in infants …

Long-term medical treatment in congenital hyperinsulinism: a descriptive analysis in a large cohort of patients from different clinical centers

A Welters, C Lerch, S Kummer, J Marquard… - Orphanet journal of rare …, 2015 - Springer
Background Up to now, only limited data on long-term medical treatment in congenital
hyperinsulinism (CHI) is available. Moreover, most of the drugs used in CHI are therefore not …

Clinical practice guidelines for congenital hyperinsulinism

T Yorifuji, R Horikawa, T Hasegawa… - clinical pediatric …, 2017 - jstage.jst.go.jp
Congenital hyperinsulinism is a rare condition, and following recent advances in diagnosis
and treatment, it was considered necessary to formulate evidence-based clinical practice …

Congenital chylothorax: a prospective nationwide epidemiological study in Germany

A Bialkowski, CF Poets, AR Franz… - Archives of Disease in …, 2015 - fn.bmj.com
Background Congenital chylothorax (CCT) is a rare disease of unknown aetiology.
Treatment approaches vary; none has been evaluated prospectively. Objective To …

Octreotide use and safety in infants with hyperinsulinism

AW McMahon, GT Wharton, P Thornton… - … and drug safety, 2017 - Wiley Online Library
Background Octreotide is a synthetic peptide analog of naturally occurring somatostatin.
Octreotide is used off‐label in children< 6 years of age for hyperinsulinism, chylothorax, and …