Aspergillus fumigatus and Aspergillosis in 2019

JP Latgé, G Chamilos - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Molecular Mechanisms of Conidial Germination in Aspergillus spp

TJH Baltussen, J Zoll, PE Verweij… - … and Molecular Biology …, 2020 - Am Soc Microbiol
Aspergilli produce conidia for reproduction or to survive hostile conditions, and they are
highly effective in the distribution of conidia through the environment. In …

[PDF][PDF] Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway

LJ Jia, M Rafiq, L Radosa, P Hortschansky, C Cunha… - Cell Host & Microbe, 2023 - cell.com
The decision whether endosomes enter the degradative or recycling pathway in mammalian
cells is of fundamental importance for pathogen killing, and its malfunctioning has …

[HTML][HTML] Different Hydrophobins of Fusarium graminearum Are Involved in Hyphal Growth, Attachment, Water-Air Interface Penetration and Plant Infection

A Quarantin, B Hadeler, C Kröger, W Schäfer… - Frontiers in …, 2019 - frontiersin.org
Hydrophobins (HPs) are small secreted fungal proteins possibly involved in several
processes such as formation of fungal aerial structures, attachment to hydrophobic surfaces …

[HTML][HTML] Antigen specificity and cross-reactivity drive functionally diverse anti–Aspergillus fumigatus T cell responses in cystic fibrosis

C Schwarz, P Eschenhagen, H Schmidt… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND The fungus Aspergillus fumigatus causes a variety of clinical phenotypes in
patients with cystic fibrosis (pwCF). Th cells orchestrate immune responses against fungi …

Menacing mold: recent advances in Aspergillus pathogenesis and host defense

BY Tischler, TM Hohl - Journal of molecular biology, 2019 - Elsevier
The genus Aspergillus is ubiquitous in the environment and contains a number of species,
primarily A. fumigatus, that cause mold-associated disease in humans. Humans inhale …

Three-dimensional light sheet fluorescence microscopy of lungs to dissect local host immune-aspergillus fumigatus interactions

J Amich, Z Mokhtari, M Strobel, E Vialetto, D Sheta… - MBio, 2020 - Am Soc Microbiol
Aspergillus fumigatus is an opportunistic fungal pathogen that can cause life-threatening
invasive lung infections in immunodeficient patients. The cellular and molecular processes …

Mitogen-activated protein kinase cross-talk interaction modulates the production of melanins in Aspergillus fumigatus

AO Manfiolli, FS Siqueira, TF Dos Reis, P Van Dijck… - mbio, 2019 - Am Soc Microbiol
The pathogenic fungus Aspergillus fumigatus is able to adapt to extremely variable
environmental conditions. The A. fumigatus genome contains four genes coding for mitogen …

[HTML][HTML] Novel treatment approach for Aspergilloses by targeting germination

K Verburg, J van Neer, M Duca, H de Cock - Journal of Fungi, 2022 - mdpi.com
Germination of conidia is an essential process within the Aspergillus life cycle and plays a
major role during the infection of hosts. Conidia are able to avoid detection by the majority of …

[HTML][HTML] Mass spectrometry-based proteomics of fungal pathogenesis, host–fungal interactions, and antifungal development

B Ball, A Bermas, D Carruthers-Lay… - Journal of Fungi, 2019 - mdpi.com
The prevalence of fungal diseases is increasing on a global scale, ranging from acute to
systemic infections caused by commensal or pathogenic microorganisms, often associated …