Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Highlights• We are only beginning to understand the mechanisms of active zone assembly.•
Trafficking, protein complex assembly, and membrane anchoring mechanisms are needed.• …

Presynaptic neurexins (Nrxs) and type IIa receptor-type protein tyrosine phosphatases
(RPTPs) organize synapses through a network of postsynaptic ligands. We show that …

Protein phosphatases are major regulators of signal transduction and they are involved in
key cellular mechanisms such as proliferation, differentiation, and cell survival. Here we …

Trans-synaptic cell-adhesion molecules are critical for governing various stages of synapse
development and specifying neural circuit properties via the formation of multifarious …

Traumatic spinal cord injury produces long-term neurological damage, and presents a
significant public health problem with nearly 18,000 new cases per year in the US The injury …

LAR-type receptor phosphotyrosine-phosphatases (LAR-RPTPs) are presynaptic adhesion
molecules that interact trans-synaptically with multitudinous postsynaptic adhesion …

Chondroitin sulfate proteoglycans (CSPGs), extracellular matrix molecules that increase
dramatically following a variety of CNS injuries or diseases, have long been known for their …

The formation of mammalian synapses entails the precise alignment of presynaptic release
sites with postsynaptic receptors but how nascent cell–cell contacts translate into assembly …

In addition to its role in Alzheimer's disease, amyloid precursor protein (APP) has
physiological roles in synapse development and function. APP induces presynaptic …