Unlimited cellular proliferation depends on counteracting the telomere attrition that
accompanies DNA replication. In human cancers this usually occurs through upregulation of …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Alternative lengthening of telomeres (ALT) is likely to be an important target for anticancer
treatment as∼ 10% of cancers depend on this telomere maintenance mechanism for …

Mouse epiblast stem cells (EpiSCs) can be derived from a wide range of developmental
stages. To characterize and compare EpiSCs with different origins, we derived a series of …

Natural chromosome ends resemble double-stranded DNA breaks, but they do not activate
a damage response in healthy cells. Telomeres therefore have evolved to solve the'end …

Telomeres shorten during each cellular division, with cumulative attrition resulting in
telomeric damage and replicative senescence. Bypass of replicative senescence …

The cyclic GMP‐AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway
mediates anti‐microbial innate immunity by inducing the production of type I interferons …

Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple
rounds of replications. During tumorigenesis, cells have to acquire telomere DNA …

The mechanism of activation of the alternative lengthening of telomeres (ALT) pathway of
mammalian chromosome-end maintenance has been unclear. We have now discovered …

Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …