Regulation of gut microbiota and metabolic endotoxemia with dietary factors

N Fuke, N Nagata, H Suganuma, T Ota - Nutrients, 2019 - mdpi.com
Metabolic endotoxemia is a condition in which blood lipopolysaccharide (LPS) levels are
elevated, regardless of the presence of obvious infection. It has been suggested to lead to …

Advances in infectious disease vaccine adjuvants

J Fan, S Jin, L Gilmartin, I Toth, WM Hussein… - Vaccines, 2022 - mdpi.com
Vaccines are one of the most significant medical interventions in the fight against infectious
diseases. Since their discovery by Edward Jenner in 1796, vaccines have reduced the …

Prevotella in Pigs: The Positive and Negative Associations with Production and Health

S Amat, H Lantz, PM Munyaka, BP Willing - Microorganisms, 2020 - mdpi.com
A diverse and dynamic microbial community (known as microbiota) resides within the pig
gastrointestinal tract (GIT). The microbiota contributes to host health and performance by …

Like cures like: pharmacological activity of anti-inflammatory lipopolysaccharides from gut microbiome

TL Lin, CC Shu, YM Chen, JJ Lu, TS Wu… - Frontiers in …, 2020 - frontiersin.org
Gut microbiome maintains local gut integrity and systemic host homeostasis, where optimal
control of intestinal lipopolysaccharides (LPS) activity may play an important role. LPS …

The early-life gut microbiome and vaccine efficacy

A Jordan, SR Carding, LJ Hall - The Lancet Microbe, 2022 - thelancet.com
Vaccines are one of the greatest successes of public health, preventing millions of cases of
disease and death in children each year. However, the efficacy of many vaccines can vary …

Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics

P Garcia-Vello, F Di Lorenzo, D Zucchetta… - Pharmacology & …, 2022 - Elsevier
Lipopolysaccharides (LPS) are the main components of the external leaflet of the Gram-
negative outer membrane and consist of three different moieties: lipid A, core …

From sharks to yeasts: Squalene in the development of vaccine adjuvants

A Mendes, J Azevedo-Silva, JC Fernandes - Pharmaceuticals, 2022 - mdpi.com
Squalene is a natural linear triterpene that can be found in high amounts in certain fish liver
oils, especially from deep-sea sharks, and to a lesser extent in a wide variety of vegeTable …

Multifaceted immunomodulatory nanoliposomes: reshaping tumors into vaccines for enhanced cancer immunotherapy

YW Noh, SY Kim, JE Kim, S Kim, J Ryu… - Advanced Functional …, 2017 - Wiley Online Library
The design and synthesis of nanoparticles mimicking the key features in size, shape, and
surface molecular organization of biological objects that provide danger‐signals are …

Biosynthetically engineered lipopolysaccharide as vaccine adjuvant

A Zariri, P van der Ley - Expert review of vaccines, 2015 - Taylor & Francis
Lipopolysaccharide (LPS), a dominant component of the Gram-negative bacterial outer
membrane, is a strong activator of the innate immune system, and thereby an important …

Multifunctional immunoadjuvants for use in minimalist nucleic acid vaccines

S Abbasi, S Uchida - Pharmaceutics, 2021 - mdpi.com
Subunit vaccines based on antigen-encoding nucleic acids have shown great promise for
antigen-specific immunization against cancer and infectious diseases. Vaccines require …