State-of-the-art strategies for targeting the DNA damage response in cancer
Genomic instability is a key hallmark of cancer that arises owing to defects in the DNA
damage response (DDR) and/or increased replication stress. These alterations promote the …
damage response (DDR) and/or increased replication stress. These alterations promote the …
Cancer drug development: The missing links
AB Kunnumakkara, D Bordoloi… - Experimental …, 2019 - journals.sagepub.com
Although better science and technology has been linked with better health care, however,
reality is much different. Although America and most of Europe are equipped with most …
reality is much different. Although America and most of Europe are equipped with most …
Systematic functional annotation of somatic mutations in cancer
The functional impact of the vast majority of cancer somatic mutations remains unknown,
representing a critical knowledge gap for implementing precision oncology. Here, we report …
representing a critical knowledge gap for implementing precision oncology. Here, we report …
CellBox: interpretable machine learning for perturbation biology with application to the design of cancer combination therapy
Systematic perturbation of cells followed by comprehensive measurements of molecular and
phenotypic responses provides informative data resources for constructing computational …
phenotypic responses provides informative data resources for constructing computational …
Comprehensive characterization of protein–protein interactions perturbed by disease mutations
Technological and computational advances in genomics and interactomics have made it
possible to identify how disease mutations perturb protein–protein interaction (PPI) networks …
possible to identify how disease mutations perturb protein–protein interaction (PPI) networks …
Impact of lineage plasticity to and from a neuroendocrine phenotype on progression and response in prostate and lung cancers
Intratumoral heterogeneity can occur via phenotype transitions, often after chronic exposure
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …
to targeted anticancer agents. This process, termed lineage plasticity, is associated with …
[HTML][HTML] The emerging potential for network analysis to inform precision cancer medicine
Precision cancer medicine promises to tailor clinical decisions to patients using genomic
information. Indeed, successes of drugs targeting genetic alterations in tumors, such as …
information. Indeed, successes of drugs targeting genetic alterations in tumors, such as …
FACER: comprehensive molecular and functional characterization of epigenetic chromatin regulators
J Lu, J Xu, J Li, T Pan, J Bai, L Wang, X Jin… - Nucleic acids …, 2018 - academic.oup.com
Epigenetic alterations, a well-recognized cancer hallmark, are driven by chromatin
regulators (CRs). However, little is known about the extent of CR deregulation in cancer, and …
regulators (CRs). However, little is known about the extent of CR deregulation in cancer, and …
A systems approach to clinical oncology uses deep phenotyping to deliver personalized care
Cancer encompasses a complex, heterogeneous and dynamic group of diseases that arise
from perturbations to multiple biological networks within the body. A systems biology-based …
from perturbations to multiple biological networks within the body. A systems biology-based …
Gain-of-function mutations: an emerging advantage for cancer biology
Advances in next-generation sequencing have identified thousands of genomic variants that
perturb the normal functions of proteins, further contributing to diverse phenotypic …
perturb the normal functions of proteins, further contributing to diverse phenotypic …