Oral squamous cell carcinomas: state of the field and emerging directions
Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …
cavity. It accounts for approximately 90% of oral malignancies and impairs appearance …
Genetic alterations of TRAF proteins in human cancers
S Zhu, J Jin, S Gokhale, AM Lu, H Shan… - Frontiers in …, 2018 - frontiersin.org
The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of cytoplasmic
adaptor proteins regulate the signal transduction pathways of a variety of receptors …
adaptor proteins regulate the signal transduction pathways of a variety of receptors …
Role of CDKN2A/p16 expression in the prognostication of oral squamous cell carcinoma
Objective CDKN2A/p16 is a known tumor suppressor gene with a homologous deletion in
Oral Squamous cell carcinoma. CDKN2A/p16 is found to be inactivated in a broad spectrum …
Oral Squamous cell carcinoma. CDKN2A/p16 is found to be inactivated in a broad spectrum …
Genome-wide CRISPR screens of oral squamous cell carcinoma reveal fitness genes in the Hippo pathway
New therapeutic targets for oral squamous cell carcinoma (OSCC) are urgently needed. We
conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived …
conducted genome-wide CRISPR-Cas9 screens in 21 OSCC cell lines, primarily derived …
Systemic and local effects among patients with betel quid-related oral cancer
HC Chuang, MH Tsai, YT Lin… - … in cancer research …, 2022 - journals.sagepub.com
The major predisposing factors of developing oral cancer include smoking, alcohol drinking,
and betel quid chewing. Betel quid chewing could cause the abrasion and damage of oral …
and betel quid chewing. Betel quid chewing could cause the abrasion and damage of oral …
mTOR co-targeting strategies for head and neck cancer therapy
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy
worldwide. There is an urgent need to develop effective therapeutic approaches to prevent …
worldwide. There is an urgent need to develop effective therapeutic approaches to prevent …
DeSigN: connecting gene expression with therapeutics for drug repurposing and development
Background The drug discovery and development pipeline is a long and arduous process
that inevitably hampers rapid drug development. Therefore, strategies to improve the …
that inevitably hampers rapid drug development. Therefore, strategies to improve the …
[HTML][HTML] Genomic characterization of human papillomavirus-positive and-negative human squamous cell cancer cell lines
NN Kalu, T Mazumdar, S Peng, L Shen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Human cancer cell lines are the most frequently used preclinical models in the study of
cancer biology and the development of therapeutics. Although anatomically diverse, human …
cancer biology and the development of therapeutics. Although anatomically diverse, human …
Mutational spectrum of tobacco associated oral squamous carcinoma and its therapeutic significance
Oral squamous cell cancer (OSCC) is a common malignancy attributed to use of chewing
smokeless tobacco and smoking. Most of the targeted strategies are based on EGFR …
smokeless tobacco and smoking. Most of the targeted strategies are based on EGFR …
Cell lineage responses to photobiomodulation therapy
Photobiomodulation (PBM) therapy has been noted to promote cell proliferation and growth
in many different cell types shown both in vitro and in vivo. Currently, treatment regimens are …
in many different cell types shown both in vitro and in vivo. Currently, treatment regimens are …