[HTML][HTML] Glioma stem cells and their roles within the hypoxic tumor microenvironment
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …
unrestricted growth and proliferation and result in further modifications in cell behavior …
Cancer stem cells: current status and evolving complexities
JE Visvader, GJ Lindeman - Cell stem cell, 2012 - cell.com
The cancer stem cell (CSC) model has been established as a cellular mechanism that
contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent …
contributes to phenotypic and functional heterogeneity in diverse cancer types. Recent …
Cancer stem cells: understanding tumor hierarchy and heterogeneity
JN Rich - Medicine, 2016 - journals.lww.com
Heterogeneity within and between tumors is a well-known phenomenon that greatly
complicates the diagnosis and treatment of cancer. A large body of research indicates that …
complicates the diagnosis and treatment of cancer. A large body of research indicates that …
Cancer stem cells: the promise and the potential
JA Ajani, S Song, HS Hochster, IB Steinberg - Seminars in oncology, 2015 - Elsevier
Despite the advancement of treatment modalities, many cancer patients experience tumor
recurrence and metastasis at regional or distant sites. Evolving understanding of tumor …
recurrence and metastasis at regional or distant sites. Evolving understanding of tumor …
Targeting glioblastoma stem cells: a review on biomarkers, signal pathways and targeted therapy
X Tang, C Zuo, P Fang, G Liu, Y Qiu, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …
[HTML][HTML] A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells
Summary microRNAs regulate developmental cell-fate decisions, tissue homeostasis, and
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …
oncogenesis in distinct ways relative to proteins. Here, we show that the tumor suppressor …
The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities
Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number
of PCa patients continues to rise despite the availability of effective treatments in recent …
of PCa patients continues to rise despite the availability of effective treatments in recent …
Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal …
Exosomes are small extracellular 40–100 nm diameter membrane vesicles of late
endosomal origin that can mediate intercellular transfer of RNA s and proteins to assist …
endosomal origin that can mediate intercellular transfer of RNA s and proteins to assist …
The adaptive transition of glioblastoma stem cells and its implications on treatments
Glioblastoma is the most malignant tumor occurring in the human central nervous system
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …
with overall median survival time< 14.6 months. Current treatments such as chemotherapy …
CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges
P Grosse‐Gehling, CA Fargeas, C Dittfeld… - The Journal of …, 2013 - Wiley Online Library
The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …
models and assays, has ushered in a new era of excitement in cancer research. The …