microRNAs in action: biogenesis, function and regulation

R Shang, S Lee, G Senavirathne, EC Lai - Nature Reviews Genetics, 2023 - nature.com
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

miRNA interplay: mechanisms and consequences in cancer

M Hill, N Tran - Disease models & mechanisms, 2021 - journals.biologists.com
Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown
that miRNAs are also capable of targeting non-coding RNAs, including long non-coding …

[HTML][HTML] miRNA-based biomarkers, therapies, and resistance in Cancer

B He, Z Zhao, Q Cai, Y Zhang, P Zhang… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
Abstract MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in
size, play important roles in gene regulation, and their dysregulation is implicated in human …

Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

T Treiber, N Treiber, G Meister - Nature reviews Molecular cell biology, 2019 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Post-transcriptional control of miRNA biogenesis

G Michlewski, JF Cáceres - Rna, 2019 - rnajournal.cshlp.org
MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer

Y Chen, Y Lin, Y Shu, J He, W Gao - Molecular cancer, 2020 - Springer
As a critical internal RNA modification in higher eukaryotes, N 6-methyladenosine (m 6 A)
has become the hotspot of epigenetics research in recent years. Extensive studies on …

Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis

H Matsuyama, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …

Network regulation of microRNA biogenesis and target interaction

S Komatsu, H Kitai, HI Suzuki - Cells, 2023 - mdpi.com
MicroRNAs (miRNAs) are versatile, post-transcriptional regulators of gene expression.
Canonical miRNAs are generated through the two-step DROSHA-and DICER-mediated …