Ethnopharmacological relevance The global problem of diabetes, together with the limited
access of large numbers of patients to conventional antidiabetic medicines, continues to …

Type 1 diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …

Understanding pancreas development can provide clues for better treatments of pancreatic
diseases. However, the molecular heterogeneity and developmental trajectory of the early …

The pancreatic islet contains multiple hormone+ endocrine lineages (α, β, δ, PP and ε cells),
but the developmental processes that underlie endocrinogenesis are poorly understood …

Human pluripotent stem cell (hPSC)-derived pancreatic β cells are an attractive cell source
for treating diabetes. However, current derivation methods remain inefficient …

Abstract Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua
Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache …

Diabetic foot ulcer (DFU), a serious complication of diabetes, remains a clinical challenge.
MicroRNAs affect inflammation and may have therapeutic value in DFU. Here, we find that …

γ-Aminobutyric acid (GABA) and glucagon-like peptide-1 receptor agonist (GLP-1RA)
improve rodent β-cell survival and function. In human β-cells, GABA exerts stimulatory …

Decreased number and function of beta cells are a key aspect of diabetes mellitus
(diabetes), a disease that remains an onerous global health problem. Means of restoring …

Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by
high blood glucose levels either due to an absolute deficiency of insulin secretion or an …