Neuroinflammation is a complex inflammatory process in the central nervous system, which
is sought to play an important defensive role against various pathogens, toxins or factors that …

A major function of the immune system is to protect the host from microbial infections. The
complement system plays important roles in both the innate and the adaptive immune …

Up to half of the heritability of age-related macular degeneration (AMD) is explained by
common variants,,,,. Here, we report the identification of a rare, highly penetrant missense …

Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly
in the Western world. While AMD is a multifactorial disease, the complement system was …

The complement system is an essential part of the innate immune system that requires
careful regulation to ensure responses are appropriately directed against harmful …

Recent studies have revealed profound developmental consequences of mutations in genes
encoding proteins of the lectin pathway of complement activation, a central component of the …

Factor I (FI) is a crucial inhibitor controlling all complement pathways due to its ability to
degrade activated complement proteins C3b and C4b in the presence of cofactors such as …

The complement system is a key component of innate and adaptive immune responses.
Complement regulation is critical for prevention and control of disease. We have determined …

The atypical Hemolytic Uremic Syndrome (aHUS) is a rare thrombotic microangiopathy
leading to end stage renal disease in approximately 60% of patients. Over the last decade, a …

CUB and Sushi multiple domains 1 (CSMD1) is a transmembrane protein containing 15
consecutive complement control protein (CCP) domains, which are characteristic for …