TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation
Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a
fundamental role in the regulation of bone organogenesis through the activation of receptor …
fundamental role in the regulation of bone organogenesis through the activation of receptor …
Bone morphogenetic protein signaling in cancer; some topics in the recent 10 years
S Ehata, K Miyazono - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-β (TGF-β)
family, are multifunctional cytokines. BMPs have a broad range of functions, and …
family, are multifunctional cytokines. BMPs have a broad range of functions, and …
p63: a crucial player in epithelial stemness regulation
Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …
ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling
R Chakrabarti, Y Wei, J Hwang, X Hang… - Nature cell …, 2014 - nature.com
Emerging evidence suggests that cancer is populated and maintained by tumour-initiating
cells (TICs) with stem-like properties similar to those of adult tissue stem cells. Despite …
cells (TICs) with stem-like properties similar to those of adult tissue stem cells. Despite …
p63-related signaling at a glance
ML Fisher, S Balinth, AA Mills - Journal of cell science, 2020 - journals.biologists.com
ABSTRACT p63 (also known as TP63) is a transcription factor of the p53 family, along with
p73. Multiple isoforms of p63 have been discovered and these have diverse functions …
p73. Multiple isoforms of p63 have been discovered and these have diverse functions …
[HTML][HTML] TGFβ and matrix-regulated epithelial to mesenchymal transition
A Moustakas, P Heldin - Biochimica et Biophysica Acta (BBA)-General …, 2014 - Elsevier
Background The progression of cancer through stages that guide a benign hyperplastic
epithelial tissue towards a fully malignant and metastatic carcinoma, is driven by genetic and …
epithelial tissue towards a fully malignant and metastatic carcinoma, is driven by genetic and …
Maintaining epithelial stemness with p63
G Melino, EM Memmi, PG Pelicci, F Bernassola - Science signaling, 2015 - science.org
In stratified epithelial and glandular tissues, homeostasis relies on the self-renewing
capacity of stem cells, which are within the basal layer. The p53 family member p63 is an …
capacity of stem cells, which are within the basal layer. The p53 family member p63 is an …
Mechanisms of action of bone morphogenetic proteins in cancer
H Davis, E Raja, K Miyazono, Y Tsubakihara… - Cytokine & growth factor …, 2016 - Elsevier
The bone morphogenetic proteins (BMPs) play fundamental roles in embryonic
development and control differentiation of a diverse set of cell types. It is therefore of no …
development and control differentiation of a diverse set of cell types. It is therefore of no …
[HTML][HTML] BMP signaling and its paradoxical effects in tumorigenesis and dissemination
L Zhang, Y Ye, X Long, P Xiao, X Ren, J Yu - Oncotarget, 2016 - ncbi.nlm.nih.gov
Bone morphogenetic proteins (BMPs) play important roles in embryonic and postnatal
development by regulating cell differentiation, proliferation, motility, and survival, thus …
development by regulating cell differentiation, proliferation, motility, and survival, thus …
Inhibition of BMP signaling suppresses metastasis in mammary cancer
Bone morphogenetic proteins (BMPs) are secreted cytokines/growth factors that have
differing roles in cancer. BMPs are overexpressed in human breast cancers, but loss of BMP …
differing roles in cancer. BMPs are overexpressed in human breast cancers, but loss of BMP …