[HTML][HTML] Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development
Aptamers are short single-stranded nucleic acid sequences capable of binding to target
molecules in a way similar to antibodies. Due to various advantages such as prolonged …
molecules in a way similar to antibodies. Due to various advantages such as prolonged …
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies
The clinical applicability of G-quadruplexes (G4s) as anticancer drugs is currently being
evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the …
evaluated. Several G4 ligands and aptamers are undergoing clinical trials following the …
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
G Liu, W Du, X Sang, Q Tong, Y Wang, G Chen… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have
devastating consequences worldwide. Recently, great efforts have been made to identify …
devastating consequences worldwide. Recently, great efforts have been made to identify …
Targeting RNA G‐quadruplex in SARS‐CoV‐2: A promising therapeutic target for COVID‐19?
C Zhao, G Qin, J Niu, Z Wang, C Wang… - Angewandte …, 2021 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 has become a global threat.
Understanding the underlying mechanisms and developing innovative treatments are …
Understanding the underlying mechanisms and developing innovative treatments are …
RNA G-quadruplexes (rG4s): genomics and biological functions
Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …
have been first observed decades ago. Over the years, these four-stranded structural motifs …
Detection of genomic G-quadruplexes in living cells using a small artificial protein
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …
in essential physiological and pathological processes and serve as important drug targets …
A guide to computational methods for G-quadruplex prediction
E Puig Lombardi, A Londoño-Vallejo - Nucleic acids research, 2020 - academic.oup.com
Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …
quadruplexes (G4). Recent methodological developments have allowed the characterization …
G-quadruplexes: a promising target for cancer therapy
DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …
particular nucleic acid structure was discussed to play a role in malignant transformation and …
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
Genomic DNA and cellular RNAs can form a variety of non-B secondary structures, including
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
G-quadruplex (G4) and R-loops. G4s are constituted by stacked guanine tetrads held …
Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …