Asthma is characterized by chronic lower airway inflammation that results in airway
remodeling, which can lead to a permanent decrease in lung function. The pathophysiology …

Studies in animal models form the basis for much of our current understanding of the
pathophysiology of asthma, and are central to the preclinical development of drug therapies …

Background As one of the main functional forms of mesenchymal stem cells (MSCs), MSC-
derived extracellular vesicles (MSC-EVs) have shown an alternative therapeutic option in …

BACKGROUND Existing murine models of asthma lack many of the inflammatory and
epithelial changes that are typical of the human disease. Moreover, these models are …

Airway diseases, predominantly asthma and chronic obstructive pulmonary disease
(COPD), are among the world's most prevalent diseases. The prevalence of asthma has …

Purpose Asthma is a chronic inflammatory airway disease characterized by airway
hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in …

Purpose Asthma is a chronic airway disease characterized by airway remodeling, leading to
a progressive decline in lung function. Therapeutic agents that attenuate airway remodeling …

Asthma is a common inflammatory disease of the lower airways and is believed to be of
allergic etiology in cats. As little progress has been made in establishing rigorous criteria to …

Background: Animal models are used to mimic human asthma, however, not all models
replicate the major characteristics of the human disease. Spontaneous development of …

The pathogenesis of allergic asthma is complex, it is usually caused by immune system
imbalance. Th1, Th2, regulatory T cells (Treg) and T helper 17 (Th17) cells have an …