Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases
are tightly regulated in the cell and play crucial regulatory roles in multiple cellular …

Casein kinase 1δ/ε (CK1δ/ε) and their yeast homologue Hrr25 are essential for cell growth.
Further, CK1δ is overexpressed in several malignancies, and CK1δ inhibitors have shown …

Activating mutations in NRAS account for 15–20% of melanoma, yet effective anti-NRAS
therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an …

Background: The casein kinase 1 (CK1) family is involved in regulating many cellular
processes, including membrane trafficking, DNA damage repair, cytoskeleton dynamics …

Casein kinase 1 delta (CK1δ) and its closest homologue CK1ε are key regulators of diverse
cellular growth and survival processes such as Wnt signaling, DNA repair, and circadian …

Csnk1e, the gene encoding casein kinase 1-epsilon, has been implicated in sensitivity to
amphetamines. Additionally, a polymorphism in CSNK1E was associated with heroin …

The fine arrangement of neuronal connectivity during development involves the coordinated
action of guidance cues and their receptors. In adolescence, the dopamine circuitry is still …

Casein kinase 1 epsilon (CK1ε) and its closest homologue CK1δ are key regulators of
diverse cellular processes. We report two crystal structures of PF4800567, a potent and …

Bipolar disorder (BD) is a mood disorder with genetic and neurobiological underpinnings,
characterized primarily by recurrent episodes of mania and depression, with notable …