Nucleic acids are excellent at recognizing complementary sequences through the formation
of Watson− Crick base pairs. Since the base pairing enables the highly selective …

Helicases of the superfamily (SF) 1 and 2 are involved in virtually all aspects of RNA and
DNA metabolism. SF1 and SF2 helicases share a catalytic core with high structural …

Helicases and translocases are a ubiquitous, highly diverse group of proteins that perform
an extraordinary variety of functions in cells. Consequently, this review sets out to define a …

Checkpoint-mediated control of replicating chromosomes is essential for preventing cancer.
In yeast, Rad53 kinase protects stalled replication forks from pathological rearrangements …

SUMMARY The RecBCD enzyme of Escherichia coli is a helicase-nuclease that initiates the
repair of double-stranded DNA breaks by homologous recombination. It also degrades …

Mutations in the BRCA2 (breast cancer susceptibility gene 2) tumor suppressor lead to
chromosomal instability due to defects in the repair of double-strand DNA breaks (DSBs) by …

When duplex DNA is altered in almost any way (replicated, recombined, or repaired), single
strands of DNA are usually intermediates, and single-stranded DNA binding (SSB) proteins …

Chromatin remodellers are specialized multi-protein machines that enable access to
nucleosomal DNA by altering the structure, composition and positioning of nucleosomes. All …

Bacterial transcription termination, described mostly for Escherichia coli, occurs in three
recognized ways: intrinsic termination, an activity only of the core RNAP enzyme and …

Completion of DNA replication after replication stress depends on PCNA, which undergoes
monoubiquitination to stimulate direct bypass of DNA lesions by specialized DNA …