Structural biology of RNA polymerase II transcription: 20 years on
S Osman, P Cramer - Annual Review of Cell and …, 2020 - annualreviews.org
Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …
eukaryotic genome and a focal point for cellular regulation during development …
Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription
MAJ Morgan, A Shilatifard - Science Advances, 2023 - science.org
The past three decades have yielded a wealth of information regarding the chromatin
regulatory mechanisms that control transcription. The “histone code” hypothesis—which …
regulatory mechanisms that control transcription. The “histone code” hypothesis—which …
High-speed fluorescence image–enabled cell sorting
Fast and selective isolation of single cells with unique spatial and morphological traits
remains a technical challenge. Here, we address this by establishing high-speed image …
remains a technical challenge. Here, we address this by establishing high-speed image …
Comprehensive mapping of histone modifications at DNA double-strand breaks deciphers repair pathway chromatin signatures
Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …
driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous …
Structure of the transcription coactivator SAGA
Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the
coactivator complexes SAGA (Spt–Ada–Gcn5–acetyltransferase), and transcription factor IID …
coactivator complexes SAGA (Spt–Ada–Gcn5–acetyltransferase), and transcription factor IID …
Structure of human TFIID and mechanism of TBP loading onto promoter DNA
INTRODUCTION In eukaryotes, transcription initiation starts with the assembly of the
transcription preinitiation complex (PIC) onto promoter DNA. The PIC comprises the general …
transcription preinitiation complex (PIC) onto promoter DNA. The PIC comprises the general …
Regulation of jasmonate signaling by reversible acetylation of TOPLESS in Arabidopsis
C An, L Deng, H Zhai, Y You, F Wu, Q Zhai… - Molecular Plant, 2022 - cell.com
The plant hormone jasmonate (JA) regulates plant immunity and adaptive growth by
orchestrating a genome-wide transcriptional program. Key regulators of JA-responsive gene …
orchestrating a genome-wide transcriptional program. Key regulators of JA-responsive gene …
Structure of SAGA and mechanism of TBP deposition on gene promoters
G Papai, A Frechard, O Kolesnikova, C Crucifix… - Nature, 2020 - nature.com
Abstract SAGA (Spt–Ada–Gcn5–acetyltransferase) is a 19-subunit complex that stimulates
transcription via two chromatin-modifying enzymatic modules and by delivering the TATA …
transcription via two chromatin-modifying enzymatic modules and by delivering the TATA …
A genome-wide CRISPR screen reveals a role for the non-canonical nucleosome-remodeling BAF complex in Foxp3 expression and regulatory T cell function
Regulatory T (Treg) cells play a pivotal role in suppressing auto-reactive T cells and
maintaining immune homeostasis. Treg cell development and function are dependent on the …
maintaining immune homeostasis. Treg cell development and function are dependent on the …
Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity
Bromodomain proteins (BRD) are key chromatin regulators of genome function and stability
as well as therapeutic targets in cancer. Here, we systematically delineate the contribution of …
as well as therapeutic targets in cancer. Here, we systematically delineate the contribution of …