Crosstalk between gut microbiota and host immunity: impact on inflammation and immunotherapy
C Campbell, MR Kandalgaonkar, RM Golonka… - Biomedicines, 2023 - mdpi.com
Gut microbes and their metabolites are actively involved in the development and regulation
of host immunity, which can influence disease susceptibility. Herein, we review the most …
of host immunity, which can influence disease susceptibility. Herein, we review the most …
Short-chain fatty acids: linking diet, the microbiome and immunity
The short-chain fatty acids (SCFAs) butyrate, propionate and acetate are microbial
metabolites and their availability in the gut and other organs is determined by environmental …
metabolites and their availability in the gut and other organs is determined by environmental …
Gut microbiome immaturity and childhood acute lymphoblastic leukaemia
I Peppas, AM Ford, CL Furness, MF Greaves - Nature Reviews Cancer, 2023 - nature.com
Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Here, we
map emerging evidence suggesting that children with ALL at the time of diagnosis may have …
map emerging evidence suggesting that children with ALL at the time of diagnosis may have …
Impact of antibiotics on gut microbiome composition and resistome in the first years of life in low-to middle-income countries: A systematic review
Background Inappropriate antimicrobial usage is a key driver of antimicrobial resistance
(AMR). Low-and middle-income countries (LMICs) are disproportionately burdened by AMR …
(AMR). Low-and middle-income countries (LMICs) are disproportionately burdened by AMR …
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood
Antibiotic use in early life disrupts microbial colonization and increases the risk of
developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx) …
developing allergies and asthma. We report that mice given antibiotics in early life (EL-Abx) …
Circulating T cell profiles associate with enterotype signatures underlying hematological malignancy relapses
Early administration of azithromycin after allogeneic hematopoietic stem cell transplantation
was shown to increase the relapse of hematological malignancies. To determine the impact …
was shown to increase the relapse of hematological malignancies. To determine the impact …
The one health approach for allergic diseases and asthma
M Jutel, GS Mosnaim, JA Bernstein, S Del Giacco… - Allergy, 2023 - Wiley Online Library
Abstract The One Health approach is a collaborative and interdisciplinary strategy with focal
point on human, animal, and environmental health interconnections. One Health can …
point on human, animal, and environmental health interconnections. One Health can …
Microbiotoxicity: antibiotic usage and its unintended harm to the microbiome
The growing body of relevant clinical and experimental evidence for antibiotic-mediated
microbiome perturbation is concerning, although further causal evidence is required. Within …
microbiome perturbation is concerning, although further causal evidence is required. Within …
The Microbiome and Infectious Diseases
LP Haraoui, MJ Blaser - Clinical Infectious Diseases, 2023 - academic.oup.com
Our perception of microbes has considerably changed since the recognition of their
pathogenic potential in the 19th century. The discovery of antibiotics and their subsequent …
pathogenic potential in the 19th century. The discovery of antibiotics and their subsequent …
Vancomycin-induced gut microbial dysbiosis alters enteric neuron–macrophage interactions during a critical period of postnatal development
EM Schill, EL Joyce, AN Floyd, S Udayan… - Frontiers in …, 2023 - frontiersin.org
Vancomycin is a broad-spectrum antibiotic widely used in cases of suspected sepsis in
premature neonates. While appropriate and potentially lifesaving in this setting, early-life …
premature neonates. While appropriate and potentially lifesaving in this setting, early-life …