Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

Cellular stress responses are mediated through a series of regulatory processes that occur
at the genomic, transcriptional, post-transcriptional, translational, and post-translational …

Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules,
such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a …

Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at
DNA lesions, which is catalyzed by poly (ADP-ribose) polymerases (PARPs). This …

The abundant nuclear enzyme PARP-1, a multifunctional regulator of chromatin structure,
transcription, and genomic integrity, plays key roles in a wide variety of processes in the …

Post-translational modifications (PTMs) regulate many aspects of protein function and are
indispensable for the spatio-temporal regulation of cellular processes. The proteome-wide …

Poly (ADP-ribose) is a major regulatory macromolecule in the nucleus, where it regulates
transcription, chromosome structure, and DNA damage repair. Functions in the interphase …

In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …

ADP-ribosylation (ADPRylation) is a posttranslational modification of proteins discovered
nearly six decades ago, but many important questions remain regarding its molecular …

Summary ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of
poly (ADP-ribose)(PAR) in response to strand breaks, and it plays an important role in cell …