Epistasis, or interactions between genes, has long been recognized as fundamentally
important to understanding the structure and function of genetic pathways and the …

Research leading to the discovery of a series of mutagenic and carcinogenic heterocyclic
amines (HCAs) was inspired by the idea that smoke produced during cooking of food …

Malignant mesothelioma is an aggressive, treatment-resistant tumour, which is increasing in
frequency throughout the world. Although the main risk factor is asbestos exposure, a virus …

Genetically engineered mouse models have significantly contributed to our understanding of
cancer biology. They have proven to be useful in validating gene functions, identifying novel …

In recent years several new mouse models for lung cancer have been described. These
include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer …

Mouse models of human cancer have played a vital role in understanding tumorigenesis
and answering experimental questions that other systems cannot address. Advances …

Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human
gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a …

Susceptibility to infectious disease is influenced by multiple host genes, most of which are
low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied …

The azoxymethane (AOM) model has been widely used to investigate the pathology and
genetics of colorectal cancer in rodents. However, there has been wide variation in …

MicroRNAs (miRNAs) are short 19-to 24-nt RNA molecules that have been shown to
regulate the expression of other genes in a variety of eukaryotic systems. Abnormal …