Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems
PC Phillips - Nature Reviews Genetics, 2008 - nature.com
Epistasis, or interactions between genes, has long been recognized as fundamentally
important to understanding the structure and function of genetic pathways and the …
important to understanding the structure and function of genetic pathways and the …
Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish
T Sugimura, K Wakabayashi, H Nakagama… - Cancer …, 2004 - Wiley Online Library
Research leading to the discovery of a series of mutagenic and carcinogenic heterocyclic
amines (HCAs) was inspired by the idea that smoke produced during cooking of food …
amines (HCAs) was inspired by the idea that smoke produced during cooking of food …
Malignant mesothelioma
BWS Robinson, AW Musk, RA Lake - The Lancet, 2005 - thelancet.com
Malignant mesothelioma is an aggressive, treatment-resistant tumour, which is increasing in
frequency throughout the world. Although the main risk factor is asbestos exposure, a virus …
frequency throughout the world. Although the main risk factor is asbestos exposure, a virus …
Mouse models of cancer
DJ Cheon, S Orsulic - Annual Review of Pathology: Mechanisms …, 2011 - annualreviews.org
Genetically engineered mouse models have significantly contributed to our understanding of
cancer biology. They have proven to be useful in validating gene functions, identifying novel …
cancer biology. They have proven to be useful in validating gene functions, identifying novel …
Mouse models for human lung cancer
R Meuwissen, A Berns - Genes & development, 2005 - genesdev.cshlp.org
In recent years several new mouse models for lung cancer have been described. These
include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer …
include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer …
Genetically engineered mouse models in cancer research
JC Walrath, JJ Hawes, T Van Dyke, KM Reilly - Advances in cancer …, 2010 - Elsevier
Mouse models of human cancer have played a vital role in understanding tumorigenesis
and answering experimental questions that other systems cannot address. Advances …
and answering experimental questions that other systems cannot address. Advances …
Model systems for the study of Enterococcal colonization and infection
HMS Goh, MHA Yong, KKL Chong, KA Kline - Virulence, 2017 - Taylor & Francis
Enterococcus faecalis and Enterococcus faecium are common inhabitants of the human
gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a …
gastrointestinal tract, as well as frequent opportunistic pathogens. Enterococci cause a …
Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis
M Lipoldová, P Demant - Nature Reviews Genetics, 2006 - nature.com
Susceptibility to infectious disease is influenced by multiple host genes, most of which are
low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied …
low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied …
Azoxymethane is a genetic background-dependent colorectal tumor initiator and promoter in mice: effects of dose, route, and diet
A Bissahoyo, RS Pearsall, K Hanlon… - Toxicological …, 2005 - academic.oup.com
The azoxymethane (AOM) model has been widely used to investigate the pathology and
genetics of colorectal cancer in rodents. However, there has been wide variation in …
genetics of colorectal cancer in rodents. However, there has been wide variation in …
MicroRNA genes are frequently located near mouse cancer susceptibility loci
C Sevignani, GA Calin, SC Nnadi… - Proceedings of the …, 2007 - National Acad Sciences
MicroRNAs (miRNAs) are short 19-to 24-nt RNA molecules that have been shown to
regulate the expression of other genes in a variety of eukaryotic systems. Abnormal …
regulate the expression of other genes in a variety of eukaryotic systems. Abnormal …