Nanoparticles as drug delivery systems: a review of the implication of nanoparticles' physicochemical properties on responses in biological systems

A Yusuf, ARZ Almotairy, H Henidi, OY Alshehri… - Polymers, 2023 - mdpi.com
In the last four decades, nanotechnology has gained momentum with no sign of slowing
down. The application of inventions or products from nanotechnology has revolutionised all …

Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022 - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Tailoring materials for modulation of macrophage fate

J Li, X Jiang, H Li, M Gelinsky, Z Gu - Advanced Materials, 2021 - Wiley Online Library
Human immune system acts as a pivotal role in the tissue homeostasis and disease
progression. Immunomodulatory biomaterials that can manipulate innate immunity and …

Reprogrammable recovery and actuation behaviour of shape-memory polymers

A Lendlein, OEC Gould - Nature Reviews Materials, 2019 - nature.com
Shape memory is the capability of a material to be deformed and fixed into a temporary
shape. Recovery of the original shape can then be triggered only by an external stimulus …

Modulation of immune responses by particle size and shape

MV Baranov, M Kumar, S Sacanna… - Frontiers in …, 2021 - frontiersin.org
The immune system has to cope with a wide range of irregularly shaped pathogens that can
actively move (eg, by flagella) and also dynamically remodel their shape (eg, transition from …

Dependence of nanoparticle toxicity on their physical and chemical properties

A Sukhanova, S Bozrova, P Sokolov… - Nanoscale research …, 2018 - Springer
Studies on the methods of nanoparticle (NP) synthesis, analysis of their characteristics, and
exploration of new fields of their applications are at the forefront of modern nanotechnology …

Inorganic nanoparticles in clinical trials and translations

H Huang, W Feng, Y Chen, J Shi - Nano today, 2020 - Elsevier
The development and application of nanotechnology-related knowledge and tools in
modern medicine has been showing great potentials in elevating human's living standards …

Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health

CN Fries, EJ Curvino, JL Chen, SR Permar… - Nature …, 2021 - nature.com
Despite the overwhelming success of vaccines in preventing infectious diseases, there
remain numerous globally devastating diseases without fully protective vaccines, particularly …

Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases

D Furtado, M Björnmalm, S Ayton, AI Bush… - Advanced …, 2018 - Wiley Online Library
Therapies directed toward the central nervous system remain difficult to translate into
improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably …