One of the complex challenges faced presently by tissue engineering (TE) is the
development of vascularized constructs that accurately mimic the extracellular matrix (ECM) …

The bioengineering of artificial tissue constructs requires special attention to their fast
vascularization to provide cells with sufficient nutrients and oxygen. We addressed the …

The generation of 3D structures comprises three interlinked phases: material development,
the printing process, and post-printing treatment. Numerous factors control all three phases …

Lipedema is a connective tissue disorder characterized by increased dilated blood vessels
(angiogenesis), inflammation, and fibrosis of the subcutaneous adipose tissue. This project …

Tissue-engineered skin substitutes are promising tools to cover large and deep skin defects.
However, the lack of a synergic and fast regeneration of the vascular network, nerves, and …

Solubilized, gel-forming decellularized extracellular matrix (dECM) is used in a wide range
of basic and translational research and due to its inherent bioactivity can promote structural …

One of the foremost targets in the advancement of biomaterials to engineer vascularized
tissues is not only to replicate the composition of the intended tissue but also to create …

Delayed fracture healing is a burden for patients as well as the health care system.
Moreover, 5–10% of all fractures show a delay in healing or even result in non-unions. One …

Preclinical testing is necessary to investigate the safety and efficacy of novel therapeutics
before moving to clinical trials, yet approximately 90% of these therapies fail once tested in …

Colorectal cancer is the second most common cause of cancer-related deaths in the United
States, with the relative 5-year survival rate for distant stage cancer being only 14%. The …