The sarcomere as the smallest contractile unit is prone to alterations in its functional,
structural and associated proteins. Sarcomeric dysfunction leads to heart failure or …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Background Mutations in filamin-C (FLNC) are involved in the pathogenesis of
arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy (DCM), and have been …

The border zone (BZ) of the infarcted heart is a geographically complex and biologically
enigmatic interface separating poorly perfused infarct zones (IZs) from remote zones (RZs) …

The history of arrhythmogenic cardiomyopathy (AC) as a genetically determined
desmosomal disease started since the original discovery by Lancisi in a four-generation …

Background: The FLNC gene has recently garnered attention as a likely cause of
arrhythmogenic cardiomyopathy, which is considered an actionable genetic condition …

The filamin C (FLNC) was hypothesized to be colocalized with its certain binding partners in
pork tissues and calpain as well as caspase was assumed responsible for the postmortem …

Background Many cardiomyopathy‐associated FLNC pathogenic variants are heterozygous
truncations, and FLNC pathogenic variants are associated with arrhythmias. Arrhythmia …

Arrhythmogenic cardiomyopathy (ACM) is an inherited myocardial disease at risk of sudden
death. Genetic testing impacts greatly in ACM diagnosis, but gene-disease associations …

Abstract Background Variants in Filamin-C (FLNC) have been associated with various
hereditary cardiomyopathies. Recent literature reports a prevalence of sudden cardiac death …