The HECT E3 ligase family regulates key cellular signaling pathways, with its 28 members
divided into three subfamilies: NEDD4 subfamily (9 members), HERC subfamily (6 …

Insoluble protein deposits are hallmarks of neurodegenerative disorders and common forms
of dementia. The aberrant aggregation of misfolded proteins involves a complex cascade of …

Estrogen and progesterone specify the establishment of uterine receptivity mainly through
their respective nuclear receptors, ER and PR. PR is transcriptionally induced by estrogen …

Distal hereditary motor neuropathies (dHMNs) are a group of inherited diseases involving
the progressive, length-dependent axonal degeneration of the lower motor neurons. There …

HACE1 is an ankyrin repeat (AKR) containing HECT‐type E3 ubiquitin ligase that interacts
with and ubiquitinates multiple substrates. While HACE1 is a well‐known tumor suppressor …

The tyrosine residue of proteins participates in a wide range of activities including enzymatic
catalysis, protein–protein interaction, and protein–ligand binding. However, the functional …

The ubiquitin-mediated degradation of oocyte translational regulatory proteins is a
conserved feature of the oocyte-to-embryo transition. In the nematode Caenorhabditis …

ABSTRACT ATG4B is a core protein and essential for cleaving precursor MAP1LC3/LC3 or
deconjugating lipidated LC3-II to drive the formation of autophagosomes. The protein …

Ubiquitin modification of viral proteins to degrade or regulate their function is one of the
strategies of the host to resist viral infection. Here, we report that ubiquitin protein ligase E3C …

Protein ubiquitination belongs to the best characterized pathways of protein degradation in
the cell; however, our current knowledge on its physiological consequences is just the tip of …