Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …

Cell therapy is an accessible method for curing damaged organs or tissues. Yet, this
approach is limited by the delivery efficiency of cell suspension injection. Over recent years …

The American Heart Association makes every effort to avoid any actual or potential conflicts
of interest that may arise as a result of an outside relationship or a personal, professional, or …

Matching material degradation with host remodeling, including endothelialization and
muscular remodeling, is important to vascular regeneration. We fabricated 3D PGS-PCL …

Many cell-based therapies are challenged by the poor localization of introduced cells and
the use of biomaterial scaffolds with questionable biocompatibility or bio-functionality …

Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide.
Ischemia and hypoxia following myocardial infarction (MI) cause subsequent cardiomyocyte …

Newborn mice and piglets exhibit natural heart regeneration after myocardial infarction (MI).
Discovering other mammals with this ability would provide evidence that neonatal cardiac …

Background Type 2 diabetes mellitus (T2DM) frequently coexists with obstructive coronary
artery disease (OCAD), which are at increased risk for cardiovascular morbidity and …

Background There is a critical need for the management of large bone defects. The purpose
of this study was to engineer a biomimetic periosteum and to combine this with a …

Background—Neuregulin-1β (NRG) is a member of the epidermal growth factor family
possessing a critical role in cardiomyocyte development and proliferation. Systemic …