Cancer epigenomics: beyond genomics
J Sandoval, M Esteller - Current opinion in genetics & development, 2012 - Elsevier
For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …
Precursor lesions for sporadic pancreatic cancer: PanIN, IPMN, and MCN
M Distler, D Aust, J Weitz, C Pilarsky… - BioMed research …, 2014 - Wiley Online Library
Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the
lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed …
lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed …
Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia
J Nordlund, CL Bäcklin, P Wahlberg, S Busche… - Genome biology, 2013 - Springer
Background Although aberrant DNA methylation has been observed previously in acute
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell of origin
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia,
which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified …
which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified …
Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …
[HTML][HTML] Advances in pancreatic cancer biomarkers
Biomarkers play an essential role in the management of patients with invasive cancers.
Pancreatic ductal adenocarcinoma (PDC) associated with poor prognosis due to advanced …
Pancreatic ductal adenocarcinoma (PDC) associated with poor prognosis due to advanced …
A study of the influence of sex on genome wide methylation
Sex differences in methylation status have been observed in specific gene-disease studies
and healthy methylation variation studies, but little work has been done to study the impact …
and healthy methylation variation studies, but little work has been done to study the impact …
Surgical and molecular pathology of pancreatic neoplasms
WM Hackeng, RH Hruban, GJA Offerhaus… - Diagnostic …, 2016 - Springer
Background Histologic characteristics have proven to be very useful for classifying different
types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long …
types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long …
Integrated single-cell multiomics analysis reveals novel candidate markers for prognosis in human pancreatic ductal adenocarcinoma
The epigenomic abnormality of pancreatic ductal adenocarcinoma (PDAC) has rarely been
investigated due to its strong heterogeneity. Here, we used single-cell multiomics …
investigated due to its strong heterogeneity. Here, we used single-cell multiomics …
Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma
Purpose: The goal of this study was to comprehensively identify CpG island methylation
alterations between pancreatic cancers and normal pancreata and their associated gene …
alterations between pancreatic cancers and normal pancreata and their associated gene …