Injectable drug delivery systems for osteoarthritis and rheumatoid arthritis

MC Bruno, MC Cristiano, C Celia, N d'Avanzo… - ACS …, 2022 - ACS Publications
Joint diseases are one of the most common causes of morbidity and disability worldwide.
The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which …

Human serum albumin based nanodrug delivery systems: recent advances and future perspective

C Li, D Zhang, Y Pan, B Chen - Polymers, 2023 - mdpi.com
With the success of several clinical trials of products based on human serum albumin (HSA)
and the rapid development of nanotechnology, HSA-based nanodrug delivery systems …

Radicals scavenging MOFs enabling targeting delivery of siRNA for rheumatoid arthritis therapy

L Guo, S Zhong, P Liu, M Guo, J Ding, W Zhou - Small, 2022 - Wiley Online Library
Macrophages play essential roles in the progression of rheumatoid arthritis (RA), which are
polarized into the pro‐inflammatory M1 phenotype with significant oxidative stress and …

Multifunctional Janus nanoplatform for efficiently synergistic theranostics of rheumatoid arthritis

Y Liu, L Chen, Z Chen, M Liu, X Li, Y Kou, MM Hou… - ACS …, 2023 - ACS Publications
Progress has been made in the application of nanomedicine in rheumatoid arthritis (RA)
treatment. However, the whole process of monitoring and treatment of RA remains a …

Spatiotemporal catalytic nanozymes microneedle patches with opposite properties for wound management

J Shan, X Zhang, L Wang, Y Zhao - Small, 2023 - Wiley Online Library
Reactive oxygen species (ROS)‐mediated biological catalysis involves serial programmed
enzymatic reactions and plays an important part against infectious diseases; while the …

A multifunctional nanoaggregate‐based system for detection of rheumatoid arthritis via optoacoustic/NIR‐II fluorescent imaging and therapy via inhibiting JAK‐STAT …

J Chen, L Chen, Z She, F Zeng, S Wu - Aggregate, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes chronic pain and
serious complications, presenting a significant challenge to treat. Promising approaches for …

Multiscale structural design of MnO2@GO superoxide dismutase nanozyme for protection against antioxidant damage

Y Yu, Y Zhang, Y Wang, W Chen, Z Guo, N Song… - Nano Research, 2023 - Springer
Rational design of metallic active sites and its microenvironment is critical for constructing
superoxide dismutase (SOD) nanozymes. Here, we reported a novel SOD nanozyme …

Macrophage reprogramming via targeted ROS scavenging and COX-2 downregulation for alleviating inflammation

X Luo, H Xiong, Y Jiang, Y Fan, C Zuo… - Bioconjugate …, 2023 - ACS Publications
Inflammation-related diseases affect large populations of people in the world and cause
substantial healthcare burdens, which results in significant costs in time, material, and labor …

Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy

X Zheng, X Yu, C Wang, Y Liu, M Jia, F Lei, J Tian… - Drug Delivery, 2022 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, which is characterized
by synovial inflammation and autoimmunity. The main cause of the disease is the imbalance …

Acupoint nanocomposite hydrogel for simulation of acupuncture and targeted delivery of triptolide against rheumatoid arthritis

S Ren, H Liu, X Wang, J Bi, S Lu, C Zhu, H Li… - Journal of …, 2021 - Springer
Background Attenuating inflammatory response and relieving pain are two therapeutic
therapeutical goals for rheumatoid arthritis (RA). Anti-inflammatory and analgesic drugs are …