Over the past decade, PAS domains have been identified in dozens of signal transduction
molecules and various forms have been found in animals, plants, and prokaryotes. In this …

▪ Abstract The aryl hydrocarbon (Ah) receptor has occupied the attention of toxicologists for
over two decades. Interest arose from the early observation that this soluble protein played …

CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication …

twist and snail are members of the helix-loop-helix and zinc-finger protein families,
respectively, and determine the development of the mesoderm in Drosophila. This paper …

Development of the Drosophila CNS midline cells is dependent upon the function of the
sing/e-minded (sim) gene. Sequence analysis shows that sim is a member of the basic-helix …

We report the identification of a Drosophila locus, reversed polarity (repo). Weak repo alleles
were viable but affected glia in the optic lobe, resulting in a reversal in polarity of the …

Studies of mice and humans have revealed a number of genes that when mutated result in
severe obesity. We have studied a unique girl with early-onset obesity and a de novo …

The bHLH–PAS transcription factor SIM1 is expressed during the development of the
hypothalamic–pituitary axis in three hypothalamic nuclei: the paraventricular nucleus (PVN) …

We describe the cloning, expression and phenotypic characterisation of repo, a gene from
Drosophila melanogaster that is essential for the differentiation and maintenance of glia …

The basic–helix–loop–helix-PAS (bHLH–PAS) proteins comprise a prominent class of
transcriptional regulators that control a variety of developmental and physiological events …