Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
[HTML][HTML] The E484K mutation in the SARS-CoV-2 spike protein reduces but does not abolish neutralizing activity of human convalescent and post-vaccination sera.
One year in the coronavirus disease 2019 (COVID-19) pandemic, the first vaccines are
being rolled out under emergency use authorizations. It is of great concern that newly …
being rolled out under emergency use authorizations. It is of great concern that newly …
[HTML][HTML] SARS-CoV-2 variants with NSP12 P323L/G671S mutations display enhanced virus replication in ferret upper airways and higher transmissibility
With the emergence of multiple predominant SARS-CoV-2 variants, it becomes important to
have a comprehensive assessment of their viral fitness and transmissibility. Here, we …
have a comprehensive assessment of their viral fitness and transmissibility. Here, we …
In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects …
Y Furusawa, M Kiso, S Iida, R Uraki, Y Hirata, M Imai… - …, 2023 - thelancet.com
Summary Background The SARS-CoV-2 delta (B. 1.617. 2 lineage) variant was first
identified at the end of 2020 and possessed two unique amino acid substitutions in its spike …
identified at the end of 2020 and possessed two unique amino acid substitutions in its spike …
Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
current COVID-19 pandemic, is one of the biggest threats to public health. However, the …
current COVID-19 pandemic, is one of the biggest threats to public health. However, the …
Generation and Characterization of recombinant SARS-CoV-2 expressing reporter genes
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the
pathogen responsible for coronavirus disease 2019 (COVID-19), has devastated public …
pathogen responsible for coronavirus disease 2019 (COVID-19), has devastated public …
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose serious threats to …
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose serious threats to …
Nanoscale cellular organization of viral RNA and proteins in SARS-CoV-2 replication organelles
The SARS-CoV-2 viral infection transforms host cells and produces special organelles in
many ways, and we focus on the replication organelles, the sites of replication of viral …
many ways, and we focus on the replication organelles, the sites of replication of viral …
A rapid method for generating infectious SARS-CoV-2 and variants using mutagenesis and circular polymerase extension cloning
BK Kim, WS Choi, JH Jeong, S Oh, JH Park… - Microbiology …, 2023 - Am Soc Microbiol
The appearance of SARS-CoV-2 variants in late 2020 raised alarming global public health
concerns. Despite continued scientific progress, the genetic profiles of these variants bring …
concerns. Despite continued scientific progress, the genetic profiles of these variants bring …
The accuracy of reverse genetics systems for SARS‐CoV‐2: Circular polymerase extension reaction versus bacterial artificial chromosome
Y Furusawa, S Yamayoshi… - Influenza and Other …, 2023 - Wiley Online Library
Background Reverse genetics systems to rescue viruses from modified DNA are useful tools
to investigate the molecular mechanisms of viruses. The COVID‐19 pandemic prompted the …
to investigate the molecular mechanisms of viruses. The COVID‐19 pandemic prompted the …