[HTML][HTML] Kratom—pharmacology, clinical implications, and outlook: a comprehensive review

SC Eastlack, EM Cornett, AD Kaye - Pain and therapy, 2020 - Springer
Kratom, or Mitragyna, is a tropical plant indigenous to Southeast Asia, with unique
pharmacological properties. It is commonly consumed by preparing the leaves into …

[HTML][HTML] Herb-induced liver injury: Systematic review and meta-analysis

VR Ballotin, LG Bigarella… - World Journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND The use of herbal supplements and alternative medicines has been
increasing in the last decades. Despite popular belief that the consumption of natural …

Kratom (Mitragyna Speciosa) Liver Injury: A Comprehensive Review

J Schimmel, RC Dart - Drugs, 2020 - Springer
Kratom (Mitragyna speciosa) leaves contain the mu opioid partial agonists mitragynine and
7-hydroxymitragynine. The US Drug Enforcement Agency considers it a 'drug of concern' …

Pharmacologic and clinical assessment of kratom: An update

CM White - American Journal of Health-System Pharmacy, 2019 - academic.oup.com
Purpose This article presents updated information on kratom (Mitragyna speciosa), a natural
opioid with stimulant properties that is currently sold in the United States without a …

Omissions, ambiguities, and underuse of causal assessment tools: A systematic review of case reports on patients who use kratom

JD Feldman, D Schriefer, KE Smith, ST Weiss… - Current Addiction …, 2023 - Springer
Purpose of review In this systematic review, we examined case reports of patients who use
kratom and evaluated their rigor based on reporting of clinically relevant information. Recent …

[HTML][HTML] Herb-induced liver injury (HILI) with 12,068 worldwide cases published with causality assessments by Roussel Uclaf Causality Assessment Method (RUCAM) …

R Teschke, A Eickhoff, J Schulze… - Translational …, 2021 - ncbi.nlm.nih.gov
Herbal products including herbal medicines are worldwide used in large amounts for
treating minor ailments and for disease prevention. However, efficacy of most herbal …

Clinical Pharmacology of the Dietary Supplement Kratom (Mitragyna speciosa)

C Hartley, M Bulloch, SR Penzak - The Journal of Clinical …, 2022 - Wiley Online Library
Kratom (Mitragyna speciosa) consists of over 40 alkaloids, with 2 of them, mitragynine and 7‐
OH‐mitragynine (7‐OH‐MG) being the main psychoactive compounds. Mitragynine and 7 …

[HTML][HTML] Kratom from head to toe—case reviews of adverse events and toxicities

E Alsarraf, J Myers, S Culbreth, J Fanikos - Current Emergency and …, 2019 - Springer
Abstract Purpose of Review This review describes case reports for patients with kratom-
associated adverse events in order to assist clinicians with patient management. A stepwise …

[HTML][HTML] Case report: treatment of kratom use disorder with a classical tricyclic antidepressant

AE Vento, S De Persis, S De Filippis, F Schifano… - Frontiers in …, 2021 - frontiersin.org
Kratom or Mitragyna speciosa (Korth.) is an evergreen tree of the coffee family native to
South-East Asia and Australasia. It is used by locals recreationally to induce stimulant and …

[HTML][HTML] Kratom (Mitragyna speciosa): Friend or Foe?

R Sethi, N Hoang, DA Ravishankar… - The Primary Care …, 2020 - psychiatrist.com
Increased use of the opioid-related plant kratom as an alternative treatment for opioid
withdrawal symptoms has raised concerns regarding its potential for abuse and severe …