Modeling membrane reshaping driven by dynamic protein assemblies

Y Fu, ME Johnson - Current opinion in structural biology, 2023 - Elsevier
Remodeling of membranes in living systems is almost universally coupled to self-assembly
of soluble proteins. Proteins assemble into semi-rigid shells that reshape attached …

Simulated dynamic cholesterol redistribution favors membrane fusion pore constriction

AH Beaven, K Sapp, AJ Sodt - Biophysical Journal, 2023 - cell.com
Endo-and exocytosis proceed through a highly strained membrane fusion pore topology
regardless of the aiding protein machinery. The membrane's lipid components bias fusion …

Probing Ionic Liquid Toxicity through Biophysical and Computational Methods

MS Padilla, S Mecozzi - Journal of Molecular Liquids, 2023 - Elsevier
Ionic liquids (ILs) have emerged as a promising class of materials due to their unique
physicochemical and solvation properties. As a result of their ionic nature, ILs have been …

Softening in two-component lipid mixtures by spontaneous curvature variance

A Hossein, AH Beaven, K Sapp… - The Journal of Physical …, 2024 - ACS Publications
The bending modulus of a lipid bilayer quantifies its mechanical resistance to curvature. It is
typically understood in terms of thickness; eg, thicker bilayers are usually stiffer. Here, we …

Dynamic cholesterol redistribution favors membrane fusion pore constriction

AH Beaven, K Sapp, AJ Sodt - bioRxiv, 2022 - biorxiv.org
Previous experiments have shown that cholesterol strongly prefers concave leaflets (which
have negative curvature and are typically thin), but cholesterol also orders and thickens …