The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

The vascular endothelium is an interface between the blood stream and the vessel wall.
Changes in this single cell layer of the artery wall are believed of primary importance in the …

The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ET A and ET B, with equal affinity, whereas …

Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social
communication, and protection against harmful effects of solar radiation. Melanogenesis is …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac
hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress …

Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …

A peptidergic activity produced in endothelial cells that caused coronary vasoconstriction
was described in 1985, 1 and a family of peptides, named the endothelins, was …

The endothelin system consists of two G-protein-coupled receptors, three peptide ligands,
and two activating peptidases. Its pharmacological complexity is reflected by the diverse …