miRNAs as cornerstones in adipogenesis and obesity
In recent decades, obesity has extensively emerged to the level of pandemics. It's
significantly associated with serious co-morbidities that could decrease life quality and even …
significantly associated with serious co-morbidities that could decrease life quality and even …
The clinical potential of circulating microRNAs in obesity
C Ji, X Guo - Nature Reviews Endocrinology, 2019 - nature.com
Obesity is a complex condition that is characterized by excessive fat accumulation, which
can lead to the development of metabolic disorders, such as type 2 diabetes mellitus …
can lead to the development of metabolic disorders, such as type 2 diabetes mellitus …
Editorial focus: understanding off-target effects as the key to successful RNAi therapy
R Bartoszewski, AF Sikorski - Cellular & molecular biology letters, 2019 - Springer
With the first RNA interference (RNAi) drug (ONPATTRO (patisiran)) on the market, we
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
witness the RNAi therapy field reaching a critical turning point, when further improvements in …
miRNAs as biomarkers and possible therapeutic strategies in rheumatoid arthritis
T Kmiołek, A Paradowska-Gorycka - Cells, 2022 - mdpi.com
Within the past years, more and more attention has been devoted to the epigenetic
dysregulation that provides an additional window for understanding the possible …
dysregulation that provides an additional window for understanding the possible …
[HTML][HTML] Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease
JL Torres, I Novo-Veleiro, L Manzanedo… - World journal of …, 2018 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small non-coding RNAs that regulate multiple physiological and
pathological functions through the modulation of gene expression at the post-transcriptional …
pathological functions through the modulation of gene expression at the post-transcriptional …
miR-221-3p drives the shift of M2-macrophages to a pro-inflammatory function by suppressing JAK3/STAT3 activation
L Quero, AN Tiaden, E Hanser, J Roux, A Laski… - Frontiers in …, 2020 - frontiersin.org
Objectives: Macrophages are conventionally classified as pro-inflammatory (M1) and anti-
inflammatory (M2) functional types. There is evidence for a predominance of macrophages …
inflammatory (M2) functional types. There is evidence for a predominance of macrophages …
MicroRNAs and immunity in periodontal health and disease
MicroRNAs (miRNAs) are critical regulators of the host immune and inflammatory response
against bacterial pathogens. In the present review, we discuss target genes, target gene …
against bacterial pathogens. In the present review, we discuss target genes, target gene …
The emerging role of epigenetics in inflammation and immunometabolism
Recent research developments have shed light on the risk factors contributing to metabolic
complications, implicating both genetic and environmental factors, potentially integrated by …
complications, implicating both genetic and environmental factors, potentially integrated by …
microRNAs distinctively regulate vascular smooth muscle and endothelial cells: functional implications in angiogenesis, atherosclerosis, and in-stent restenosis
G Santulli - microRNA: Basic Science: From Molecular Biology to …, 2015 - Springer
Endothelial cells (EC) and vascular smooth muscle cells (VSMC) are the main cell types
within the vasculature. We describe here how microRNAs (miRs)—noncoding RNAs that …
within the vasculature. We describe here how microRNAs (miRs)—noncoding RNAs that …
Immunobiology of parasitic worm extracellular vesicles
RM Eichenberger, J Sotillo… - Immunology and cell …, 2018 - Wiley Online Library
Helminth parasites (worms) have evolved a vast array of strategies to manipulate their
vertebrate hosts. Extracellular vesicles (EV s) are secreted by all helminth species …
vertebrate hosts. Extracellular vesicles (EV s) are secreted by all helminth species …